Bioresorbable polymeric sutures are gaining interest from surgeons and patients as they reduce surgical stress and trauma. This study involves two bioresorbable polymers, namely, catgut and poly(4-hyrdorxybutyrate) (P4HB) that are used widely in cosmetic procedures. P4HB barbed sutures are favorably used in rhytidectomy (micro-facelifts) procedures while catgut sutures are widely used for external wound closure after surgical interventions. This study involves the mechanical fabrication of catgut and P4HB barbed sutures and compares their mechanical and anchoring properties. Barbed sutures were fabricated with two different barb geometries namely, straight and curved barbs. The mechanical properties were evaluated via tensile testing, and the anchoring performance was studied by means of a suture-tissue pull-out protocol using porcine dermis tissue which was harvested from the medial dorsal site. The fabricated barbed sutures of both materials showed a similar trend compared to non-barbed sutures of decreases in failure stress, strain at failure, and work to rupture or toughness which was reduced by about 70%. At the same time there was a 15% increase in the initial modulus or stiffness of the barbed sutures. The pull-out force for the barbed sutures with straight barbs was similar for both P4HB (5.04 ± 0.8 N) and catgut (4.47 ± 3.8 N), and as expected, were higher than that of non-barbed sutures of the same size. It was also observed that barbed sutures with curved barbs also required a higher pull-out force than those sutures with straight barbs. It was concluded that by barbing sutures with different barb shapes and geometries, a range of barbed suture products could be fabricated, each meeting the closure requirements for different types of tissue and therefore being suitable for different surgical procedures.

中文翻译：

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不同倒刺几何形状的生物可吸收倒刺缝合线的机械制造和评估

生物可吸收聚合物缝合线因其减少手术压力和创伤而引起外科医生和患者的兴趣。这项研究涉及两种生物可吸收聚合物，即肠线和聚（4-羟基丁酸酯）（P4HB），它们广泛用于美容手术。 P4HB 有倒刺缝合线适用于除皱术（微整容）手术，而肠线缝合线则广泛用于手术干预后的外部伤口闭合。本研究涉及肠线和 P4HB 有刺缝合线的机械制造，并比较它们的机械和锚固性能。有倒刺的缝合物被制造成具有两种不同的倒刺几何形状，即直倒刺和弯曲倒刺。通过拉伸测试评估机械性能，并使用从内侧背部部位收获的猪真皮组织通过缝合组织拉出方案研究锚定性能。与无倒刺缝合线相比，两种材料制成的有倒刺缝合线显示出类似的趋势，即失效应力、失效应变以及断裂功或韧性降低了约 70%。同时，带刺缝合线的初始模量或刚度增加了 15%。 P4HB (5.04 ± 0.8 N) 和肠线 (4.47 ± 3.8 N) 的直倒刺缝合线的拉拔力相似，并且如预期的那样，高于相同尺寸的无倒刺缝合线的拉拔力。还观察到，具有弯曲倒刺的有倒钩缝合线也比具有直倒刺的缝合线需要更高的拉拔力。结论是，通过具有不同倒刺形状和几何形状的倒刺缝合线，可以制造一系列倒刺缝合线产品，每种产品满足不同类型组织的闭合要求，因此适合不同的外科手术。