Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, injectable, sticky, highly porous, and has good swelling properties, antibacterial activity, and cell compatibility. Based on its good performance in vitro, sericin-honey hydrogel achieved effective in vivo treatment on a mouse diabetic wound model, significantly accelerating the wound healing process. Furthermore, the combined effect of feeding sericin solution played a positive role in strengthening the effect of diabetic wound repair.

中文翻译：

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具有抗氧化和抗菌活性的透明注射丝胶-蜂蜜水凝胶结合喂养丝胶加速糖尿病伤口愈合

由于高活性氧和低抗氧化剂水平的存在，糖尿病患者的伤口愈合常常受到损害或延迟。在此，制备了具有优异抗氧化活性的丝胶-蜂蜜半互穿网络水凝胶。此外，丝胶-蜂蜜水凝胶透明、可注射、粘性、高孔隙度，具有良好的溶胀性、抗菌活性和细胞相容性。基于其良好的性能体外, 丝胶-蜂蜜水凝胶取得了有效体内对小鼠糖尿病伤口模型进行治疗，显着加速伤口愈合过程。此外，饲喂丝胶溶液的综合作用对加强糖尿病创面修复效果起到了积极作用。