Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe₃O₄@Poly (diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100–300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe₃O₄ enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.

中文翻译：

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用于动脉栓塞、化疗和成像的三合一多功能碘油掺杂 Fe3O4@聚（间苯二甲酸二烯丙酯）微球的合成和表征

经导管动脉栓塞术在治疗多种疾病中发挥着举足轻重的作用。然而，栓塞治疗在癌症治疗中的疗效可能受到多种因素的限制，例如不可避免的不完全或非靶向栓塞，以及缺氧微环境导致的肿瘤复发和转移。此外，有必要探索更简单、更经济、更高效的微球合成方法。在此，我们实现了一步光催化合成碘油掺杂的Fe ₃ O ₄ @Poly（二烯丙基）异-邻苯二甲酸盐）多功能微球（IFeD MS），用于动脉栓塞、化疗和成像。制备的微球呈梅干状，粒径为100~300 μm。碘化油表现出一定程度的化疗活性，Fe ₃ O ₄的掺入使微球表现出磁热响应和磁共振成像能力。此外，两种药物的不透射线特性为微球提供了计算机断层扫描和数字放射线成像的广阔前景。家兔肾脏栓塞实验表明，IFeD MS取得了显着的栓塞和化疗效果。生物相容性实验表明，这种栓塞剂不会引起治疗区域以外的组织损伤或炎症。此外，IFeD MS 展现出广阔的成像潜力。这项研究的结果表明，所开发的多功能栓塞剂IFeD MS可能具有将以前只适合姑息治疗的肿瘤转变为可切除的根治性治疗的巨大潜力。