This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology research across a diverse array of mammalian species.

The mammary gland's unique development and regenerative capabilities render this organ an ideal model for studying developmental evolution, stem cell behavior, and regenerative processes. The discussion extends to the use of cross-species mammary organoids to address key biological inquiries in evolution, tissue regeneration, cancer research, and lactation, highlighting the limitations of traditional mouse models and the benefits of incorporating a more diverse range of animal models.

Advances in organoid biology have been critical in overcoming ethical and practical constraints of in-vivo studies, especially in human research. The generation of human and mouse mammary organoids that faithfully recapitulate in-vivo tissues marks a significant stride in this field. Parallel capabilities are now emerging for other mammals, as well.

Utilizing mammary organoids from various species has the potential to make invaluable contributions to our understanding of mammary gland biology, with implications for regenerative medicine, cancer research, and lactation studies, thereby contributing to advancements in human health, agriculture, and nutrition science.

本文全面阐述了类器官技术对多种哺乳动物乳腺生物学研究的变革作用。

乳腺独特的发育和再生能力使该器官成为研究发育进化、干细胞行为和再生过程的理想模型。讨论延伸到使用跨物种乳腺类器官来解决进化、组织再生、癌症研究和哺乳方面的关键生物学问题，强调了传统小鼠模型的局限性以及纳入更多样化的动物模型的好处。

类器官生物学的进步对于克服体内研究的伦理和实践限制至关重要，特别是在人类研究中。忠实再现体内组织的人类和小鼠乳腺类器官的产生标志着该领域的重大进步。其他哺乳动物也出现了类似的能力。

利用来自不同物种的乳腺类器官有可能为我们对乳腺生物学的理解做出宝贵的贡献，对再生医学、癌症研究和哺乳研究具有影响，从而促进人类健康、农业和营养科学的进步。