Introduction

Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosis of patients with BMs. The purpose of this study is to develop a prognostic score in palliative pts with BMs who undergo WBRT in this new setting.

Methods

239 pts with BMs who received palliative WBRT between 2013–2022 in our center were analyzed retrospectively. The score was designed according to the value of the β coefficient of each variable with statistical significance in the multivariate model using Cox regression. Once the score was established, a comparison was performed according to Kaplan–Meier and was analyzed by log-rank test.

Results

149 pts (62.3%) were male and median (m) age was 60 years. 139 (58,2%) were lung cancer and 35 (14,6%) breast cancer. All patients received 30Gys in 10 sessions. m overall survival (OS) was 3,74 months (ms). 37 pts (15,5%) had a specific target mutation. We found that 62 pts were in group < 4 points with mOS 6,89 ms (CI 95% 3,18–10,62), 84 in group 4–7 points with mOS 4,01 ms (CI 95% 3,40–4,62) and 92 pts in group > 7 points with mOS 2,72 ms (CI 95% 1,93–3,52) (p < 0,001).

Conclusions

METASNCore items are associated with OS and they could be useful to select palliative pts to receive WBRT. More studies are necessary to corroborate our findings.

中文翻译：

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精准肿瘤学时代接受姑息性全脑放疗 (WBRT) 治疗的脑转移瘤 (BM) 患者的最新预后指数。 METASN核心项目

介绍

姑息性 WBRT 是多种 BM 的主要治疗方法。最近的研究表明，与姑息支持治疗相比，对于预后不良的患者，WBRT 后的生存率没有任何益处。基于靶向治疗的系统治疗策略的新时代正在改善脑转移患者的预后。本研究的目的是为在这种新环境中接受 WBRT 的 BM 姑息患者制定预后评分。

方法

对 2013 年至 2022 年期间在我中心接受姑息性 WBRT 的 239 例 BM 患者进行回顾性分析。使用Cox回归根据多变量模型中具有统计显着性的每个变量的β系数值来设计评分。一旦评分确定，就根据 Kaplan-Meier 进行比较，并通过对数秩检验进行分析。

结果

149 名患者 (62.3%) 为男性，中位年龄 (m) 为 60 岁。 139 例 (58.2%) 为肺癌，35 例 (14.6%) 为乳腺癌。所有患者均接受 30Gys 10 次治疗。总生存期 (OS) 为 3.74 个月 (ms)。 37 名患者（15.5%）有特定的目标突变。我们发现，62 名患者属于 < 4 分组，mOS 6,89 ms (CI 95% 3,18–10,62)，84 名患者属于 4–7 分组，mOS 4,01 ms (CI 95% 3,40) –4,62) 和组中 92 名患者> 7 分，mOS 2,72 ms (CI 95% 1,93–3,52) ( p  < 0,001)。

结论

METASNCore 项目与操作系统相关，它们对于选择姑息治疗患者接受 WBRT 可能很有用。需要更多的研究来证实我们的发现。