Intestinal wound healing is a long-standing problem, with conventional suturing-based intestinal closure surgeries typically leading to postoperative problems. Alternative strategies or devices capable of effective wound healing have thus been sought. Here we report a self-powered electronic bandage made from soft and biodegradable materials that can accelerate wound healing in the intestine. The device uses dual electrostimulation to promote wound healing: a pulsed electrostimulation that induces electrotransfection of epithelial cells, promoting the expression of healing factors (such as epithelial growth factor); and a d.c. electrostimulation that enhances secretion of healing factors of the transfected cells. The electronic bandage exhibits high transfection efficiency and cell viability for intestinal epithelial cells in vitro, which boosts epithelial growth factor expression during the intraoperative period. Its self-powered galvanic cell from a magnesium and molybdenum microelectrode pair promotes healing factor exocytosis. In vitro and in vivo studies in mice show accelerated intestinal would healing compared to conventional suture-based treatments and an electronic bandage with single electrostimulation.

肠道伤口愈合是一个长期存在的问题，传统的基于缝合的肠道闭合手术通常会导致术后问题。因此，人们一直在寻找能够有效治愈伤口的替代策略或装置。在这里，我们报告了一种由柔软且可生物降解的材料制成的自供电电子绷带，可以加速肠道伤口的愈合。该设备采用双重电刺激促进伤口愈合：脉冲电刺激诱导上皮细胞电转染，促进愈合因子（如上皮生长因子）的表达；以及增强转染细胞愈合因子分泌的直流电刺激。电子绷带在体外对肠上皮细胞表现出高转染效率和细胞活力，可增强术中上皮生长因子的表达。其来自镁和钼微电极对的自供电原电池可促进愈合因子的胞吐作用。对小鼠的体外和体内研究表明，与传统的基于缝合的治疗和单次电刺激的电子绷带相比，可加速肠道愈合。