Metabolomic analysis of cerebrospinal fluid (CSF) is used to improve diagnostics and pathophysiological understanding of neurological diseases. Alterations in CSF metabolite levels can partly be attributed to changes in brain metabolism, but relevant transport processes influencing CSF metabolite concentrations should be considered. The entry of molecules including metabolites into the central nervous system (CNS), is tightly controlled by the blood-brain, blood-CSF, and blood-spinal cord barriers, where aquaporins and membrane-bound carrier proteins regulate influx and efflux via passive and active transport processes. This report therefore provides reference for future CSF metabolomic work, by providing a detailed summary of the current knowledge on the location and function of the involved transporters and routing of metabolites from blood to CSF and from CSF to blood.

中文翻译：

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跨越中枢神经系统屏障的代谢转运

脑脊液 (CSF) 的代谢组学分析用于改善神经系统疾病的诊断和病理生理学理解。脑脊液代谢物水平的改变可部分归因于脑代谢的变化，但应考虑影响脑脊液代谢物浓度的相关运输过程。包括代谢物在内的分子进入中枢神经系统 (CNS) 受到血脑、血脑脊液和血脊髓屏障的严格控制，其中水通道蛋白和膜结合载体蛋白通过被动和主动运输过程。因此，本报告详细总结了有关转运蛋白的位置和功能以及代谢物从血液到脑脊液以及从脑脊液到血液的路径的当前知识，为未来脑脊液代谢组学工作提供参考。