ObjectivesResearch progress of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) based on immune microenvironment.MethodsThis article preliminarily discusses the composition of immune microenvironment components and immune therapy and elaborates and analyzes the involvement and impact of T cells, B cells, natural killer (NK) cells, tumor-associated fibroblasts, and bone marrow-derived suppressor cells in HPV-positive HNSCC on tumor progression and prognosis. Furthermore, the application of immune-related therapies in HPV-positive HNSCC is explored.ResultsIt is found that immune microenvironment research plays an important role in the pathogenesis and treatment of HPV-positive HNSCC.ConclusionsImmune microenvironment research as an important means to explore tumors has played an important role in the study of HPV-positive HNSCC. We describe the biological significance of important components of HNSCC immune microenvironment by analyzing the effects of HNSCC immune microenvironment components and immunotherapy on HPV-positive HNSCC. May to provide new strategies for experimental research and clinical prevention and treatment of this disease.

中文翻译：

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人乳头瘤病毒阳性头颈鳞状细胞癌的免疫微环境

目的基于免疫微环境研究人乳头瘤病毒（HPV）阳性头颈鳞状细胞癌（HNSCC）的研究进展。方法初步探讨免疫微环境成分组成及免疫治疗，阐述分析T细胞、B细胞的参与及影响。 HPV 阳性 HNSCC 细胞、自然杀伤 (NK) 细胞、肿瘤相关成纤维细胞和骨髓源性抑制细胞对肿瘤进展和预后的影响。进一步探讨了免疫相关治疗在HPV阳性HNSCC中的应用。结果发现免疫微环境研究在HPV阳性HNSCC的发病机制和治疗中发挥着重要作用。结论免疫微环境研究作为探索肿瘤的重要手段已成为研究的热点。在 HPV 阳性 HNSCC 的研究中发挥了重要作用。我们通过分析HNSCC免疫微环境成分和免疫治疗对HPV阳性HNSCC的影响，描述HNSCC免疫微环境重要成分的生物学意义。可能为本病的实验研究和临床防治提供新策略。