The recent study by Djinbachian et al comparing accuracy of intracolonoscopic to pathology-based assessment of colorectal polyp size is of considerable interest.1 The authors reported that pathology sizing is often not possible because of piecemeal polyp resection or fragmentation during retrieval and, for intact polypectomy specimens, pathology accuracy is limited by formalin-related shrinkage. 78% of pathology-based polyp measurements were smaller than the reference postcolonoscopy size assessed by digital vernier calipre, and mean shrinkage effect was estimated at 25.7%. However, there is another aspect of the pathology assessment which has not been considered and is perhaps a more likely explanation of size reduction based on pathology measurement. While formalin-related specimen shrinkage is well established, this mainly relates to specimens with significant contractility, such as cutaneous specimens.2 Studies examining the impact of formalin on polyp sizing have yielded conflicting results, though most have suggested …

中文翻译：

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结直肠息肉大小的显微病理学评估不如结肠镜内评估准确

Djinbachian 等人最近的研究比较了结肠镜内检查与基于病理学的结直肠息肉大小评估的准确性，这一点引起了人们的极大兴趣。1 作者报告说，由于息肉在取出过程中进行分段切除或碎片化，并且对于完整的息肉切除术，病理学大小通常是不可能的。标本，病理学准确性受到福尔马林相关收缩的限制。 78% 的基于病理学的息肉测量值小于通过数字游标卡尺评估的结肠镜检查后参考尺寸，平均收缩效果估计为 25.7%。然而，病理评估的另一个方面尚未被考虑，并且可能是基于病理测量的尺寸减小的更可能的解释。虽然与福尔马林相关的标本收缩已得到充分证实，但这主要与具有显着收缩力的标本有关，例如皮肤标本。2 研究福尔马林对息肉尺寸影响的研究得出了相互矛盾的结果，尽管大多数研究表明……