TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging,Autophagy

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TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
Autophagy ( IF 13.3 ) Pub Date : 2024-03-28 , DOI: 10.1080/15548627.2024.2333717
David Sebastián _{1,

2,

3} , Marc Beltrà _{2,

3,

4} , Andrea Irazoki _{2,

3,

4} , David Sala _{2,

3,

4} , Pilar Aparicio ₅ , Cecilia Aris ₆ , Esmaeil Alibakhshi _{7,

8,

9} , Maria Rubio-Valera _{10,

11} , Manuel Palacín _{2,

4,

12} , Juan Castellanos ₅ , Luis Lores ₇ , Antonio Zorzano _{2,

3,

4}

Affiliation

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Department of Orthopedic Surgery and Traumatology, Hospital de Sant Boi Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Department of Family and Community Medicine, Hospital de Sant Boi Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Pneumology Department, Hospital de Sant Boi Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Physical Medicine and Rehabilitation Department, Clinical Research Development Unit, Baqyiatallah Hospital, Faculty of Medicine, Baqyiatallah University of Medical Science, Tehran, Iran
Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Institute, Tehran University of Medical Science, Tehran, Iran
Quality and Patient Safety Unit, Hospital de Sant Boi Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Centro de Investigación Biomédica de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophag...

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