The objective of this study was to investigate the effects of two different organic selenium (Se) supplements, selenomethionine (Se‐Met) and selenohomolanthionine (Se‐Hlan), on the serum biochemical parameters and Se status of dairy cows. Different dietary Se supplementation treatments were set as follows: a control group (CON, adding sodium selenite at 0.3 mg Se/kg dry matter [DM]), 0.3 and 0.5 Se‐Met (adding Se‐Met at 0.3 and 0.5 mg Se/kg DM, respectively), as well as 0.3 and 0.5 Se‐Hlan (adding Se‐Hlan at 0.3 and 0.5 mg Se/kg DM, respectively). The experiment lasted 8 weeks. The serum measurements showed that both organic Se treatments resulted in higher uric acid than CON. Se‐Met produced higher aspartate aminotransferase, glucose, urea, low‐density lipoprotein cholesterol, and lactate dehydrogenase than Se‐Hlan. Regarding the Se status, the highest milk Se values appeared in 0.5 Se‐Met, with intermediate values in 0.3 Se‐Met and 0.5 Se‐Hlan, whereas the highest and lowest serum Se levels were presented in 0.5 Se‐Met and 0.3 Se‐Hlan, respectively. Our results suggest that Se‐Hlan was not as efficient in boosting serum or milk Se as Se‐Met and differences in serum biomarkers between Se‐Met and Se‐Hlan may be associated with distinct metabolic pathways for different forms of organic Se.

中文翻译：

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不同有机硒补充剂对奶牛硒状况和血清生物标志物的影响比较

本研究的目的是研究两种不同的有机硒（Se）补充剂，硒代蛋氨酸（Se-Met）和硒代黄硫氨酸（Se-Hlan）对奶牛血清生化参数和硒状态的影响。不同的膳食补硒处理设置如下：对照组（CON，按 0.3 mg Se/kg 干物质 [DM] 添加亚硒酸钠）、0.3 和 0.5 Se-Met（按 0.3 和 0.5 mg Se/kg 添加 Se-Met） kg DM，分别），以及 0.3 和 0.5 Se-Hlan（分别以 0.3 和 0.5 mg Se/kg DM 添加 Se-Hlan）。实验持续了8周。血清测量结果表明，两种有机硒处理均比 CON 处理产生更高的尿酸。 Se-Met 比 Se-Hlan 产生更高的天冬氨酸转氨酶、葡萄糖、尿素、低密度脂蛋白胆固醇和乳酸脱氢酶。关于硒状态，最高的乳硒值出现在 0.5 Se-Met 中，中间值出现在 0.3 Se-Met 和 0.5 Se-Hlan 中，而最高和最低的血清硒水平出现在 0.5 Se-Met 和 0.3 Se-Hlan 中。分别是赫兰。我们的结果表明，Se-Hlan 在增加血清或乳汁硒方面不如 Se-Met 有效，并且 Se-Met 和 Se-Hlan 之间血清生物标志物的差异可能与不同形式有机硒的不同代谢途径有关。