: Novel hydrazones 4, 5, and oxime 6 were produced from the reaction of ketone 3 with hydrazine, phenylhydrazine, and hydroxylamine HCl, respectively. One pot multicomponent reaction of chalcones 7a-c, 3-(1H-indol-3-yl)-3-oxopropanenitrile 8, and ammonium acetate in MeOH at reflux temperature gave 2-(1H-indol-3-yl)-nicotinonitrile derivatives 10-12. Additionally, a one-pot reaction of chalcone 7a, malononitrile or ethyl cyanoacetate, and ammonium acetate in AcOH at reflux temperature afforded 6-aminopyridine derivatives 13 and 14, respectively.

中文翻译：

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利用4,6-二甲基-1-((4-甲基噻唑-2-基)氨基)-2-氧代-1,2-二氢吡啶-3-甲腈设计与合成新型杂环

： 酮 3 分别与肼、苯肼和盐酸羟胺反应生成新型腙 4、5 和肟 6。查尔酮 7a-c、3-(1H-吲哚-3-基)-3-氧代丙腈 8 和乙酸铵在甲醇中于回流温度下进行一锅多组分反应，得到 2-(1H-吲哚-3-基)-烟腈衍生物10-12。另外，查耳酮7a、丙二腈或氰基乙酸乙酯和乙酸铵在AcOH中在回流温度下的一锅反应分别得到6-氨基吡啶衍生物13和14。