IntroductionResting heart rate has been distinctly related to both internalizing (high pulse) and externalizing (low pulse) disorders. We aimed to explore the associations between resting heart rate and suicidal behavior (nonfatal suicide attempt [SA] and suicide death [SD]) and evaluate if such associations exist beyond the effects of internalizing/externalizing symptomatology.MethodWe used Cox proportional hazards models to evaluate the associations between resting heart rate (age 19) and later SA/SD in 357,290 Swedish men. Models were controlled for internalizing disorders, externalizing disorders, and resilience (the ability to deal with adversity). Co‐relative analysis (comparing pairs of different genetic relatedness) was used to control for unmeasured family confounders and improve causal inference.ResultsIn baseline models, low resting heart rate was associated with SA (HR = 0.96; 95% CI: 0.95,0.98) and high resting heart rate with SD (HR = 1.04; 95% CI: 1.002,1.07). The association with SA remained after adjustment for all confounders (HR = 0.98). However, the association with SD did not persist after controlling for covariates. Co‐relative analysis did not support causal associations.ConclusionsOur findings raise interesting etiological questions for the understanding of suicidal behaviors but do not support the usefulness of resting heart rate in suicide prediction.

中文翻译：

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瑞典一项基于人群的研究评估静息心率在预测男性自杀行为中的有用性

简介静息心率与内化（高脉搏）和外化（低脉搏）疾病明显相关。我们的目的是探讨静息心率和自杀行为（非致命性自杀企图[SA]和自杀死亡[SD]）之间的关联，并评估这种关联是否存在于内化/外化症状学的影响之外。方法我们使用Cox比例风险模型来评估研究了 357,290 名瑞典男性的静息心率（19 岁）与后来的 SA/SD 之间的关联。控制模型的内化障碍、外化障碍和复原力（应对逆境的能力）。相关分析（比较不同遗传相关性的配对）用于控制未测量的家庭混杂因素并改善因果推断。结果在基线模型中，低静息心率与 SA 相关（HR = 0.96；95% CI：0.95,0.98） SD 静息心率高（HR = 1.04；95% CI：1.002，1.07）。调整所有混杂因素后，与 SA 的相关性仍然存在（HR = 0.98）。然而，在控制协变量后，与 SD 的关联并没有持续存在。相关分析不支持因果关系。结论我们的研究结果为理解自杀行为提出了有趣的病因学问题，但不支持静息心率在自杀预测中的有用性。