Diazo compounds, although possessing unique reactivity, have been widely rejected due to their highly hazardous preparation protocols. Diazoacetonitrile (DAN), a relatively stable diazo compound, has been overlooked despite its potential in chemical synthesis. The present study describes a microflow process for the simultaneous preparation of DAN in aqueous solution and its extraction in dichloromethane. The DAN productivity was optimized in terms of solvent, temperature, residence time, and pressure. This experimental work represents a breakthrough in delivering DAN continuously in a stable CH₂Cl₂ solution, enabling its utilization as a versatile building block for various synthetic processes and contributing to the development of new green synthetic processes.

中文翻译：

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重氮乙腈：通过连续加工安全、绿色合成

重氮化合物虽然具有独特的反应性，但由于其高度危险的制备方案而被广泛拒绝。重氮乙腈（DAN）是一种相对稳定的重氮化合物，尽管其在化学合成方面具有潜力，但一直被忽视。本研究描述了在水溶液中同时制备 DAN 并在二氯甲烷中萃取的微流程。 DAN 生产率在溶剂、温度、停留时间和压力方面进行了优化。这项实验工作代表了在稳定的 CH ₂ Cl ₂溶液中连续提供 DAN 的突破，使其能够用作各种合成工艺的通用构建模块，并有助于开发新的绿色合成工艺。