Therapeutic plasma exchange (TPE) is an extracorporeal technique where patient’s plasma containing pathogenic substances is separated and removed from the whole blood, while the cellular component is returned to the patient mixed with replacement solution via an apheresis machine. Due to its ability to remove pathogenic substances from plasma including immunoglobulins, TPE has proven efficacious in the management of various disorders across different medical disciplines, including plasma cell dyscrasias, which are characterized by the abundant secretion of non-functional immunoglobulins produced by an abnormally proliferating plasma cell clone. This review summarizes the current indications of TPE in plasma cell-related disorders and discusses its application, safety, and therapeutic effects.

治疗性血浆置换（TPE）是一种体外技术，将患者的含有致病物质的血浆从全血中分离出来并去除，同时通过单采机将细胞成分与替代溶液混合返回患者体内。由于其能够从血浆中去除包括免疫球蛋白在内的致病物质，TPE 已被证明可有效治疗不同医学学科的各种疾病，包括浆细胞恶液质，其特点是异常增殖产生的非功能性免疫球蛋白大量分泌。浆细胞克隆。本综述总结了目前 TPE 在浆细胞相关疾病中的适应症，并讨论了其应用、安全性和治疗效果。