Tourism is one of the most important activities for the economy of Nor Patagonia Argentina. In Bariloche City, located on the shores of Lake Nahuel Huapi, both the permanent and the temporary populations have increased significantly in recent decades, and this has not necessarily been accompanied by an improvement in sewage networks. Emerging micropollutants such as pharmaceutical compounds reach aquatic systems directly, in the absence of a domestic sewage network, or through effluents from wastewater treatment plants (WWTP), which do not efficiently remove these substances and represent a major threat to the environment. Therefore, the objective of our study was to monitor the presence of pharmaceutical compounds discharged both through wastewater effluents and diffusely from housing developments into Lake Nahuel Huapi. The results obtained demonstrate the presence of pharmaceuticals in Lake Nahuel Huapi with concentrations ranging from not detectable (ND) to 110.6 ng L–1 (caffeine). The highest pharmaceutical concentration recorded in WWTP influent corresponded to caffeine (41728 ng L–1), and the lowest concentration was paracetamol (18.8 ng L–1). The removal efficiency of pharmaceuticals in the WWTP was calculated, and ranged from 0% for carbamazepine to 66% for ciprofloxacin. This antibiotic showed the lowest % of attenuation (73%) in Lake Nahuel Huapi. These results on the occurrence of a wide variety of pharmaceuticals are the first generated in Patagonia, representing a regional baseline for this type of micropollutant and valuable information for the subsequent design of removal strategies for emerging pharmaceutical pollutants in surface water. Environ Toxicol Chem 2024;00:1–11. © 2024 SETAC

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阿根廷巴塔哥尼亚纳韦尔瓦皮湖中药物微污染物的出现

旅游业是阿根廷诺巴塔哥尼亚最重要的经济活动之一。在位于纳韦尔瓦皮湖畔的巴里洛切市，近几十年来，常住人口和临时人口都大幅增加，但这并不一定伴随着污水管网的改善。在没有生活污水网络的情况下，药物化合物等新兴微污染物直接到达水生系统，或者通过废水处理厂 (WWTP) 的废水到达水生系统，而废水处理厂无法有效去除这些物质，并对环境构成重大威胁。因此，我们研究的目的是监测通过废水排放和从住宅开发扩散到纳韦尔瓦皮湖的药物化合物的存在情况。获得的结果表明纳韦尔瓦皮湖中存在药物，浓度范围从不可检测 (ND) 到 110.6 ng L–1（咖啡因）。污水处理厂进水中记录的最高药物浓度对应于咖啡因（41728 ng L–1），最低浓度为扑热息痛（18.8 ng·L–1）。计算了污水处理厂中药物的去除率，范围从卡马西平的0%到环丙沙星的66%。这种抗生素在纳韦尔瓦皮湖中的衰减百分比最低 (73%)。这些关于多种药物出现的结果是巴塔哥尼亚首次产生的，代表了此类微污染物的区域基线，并为后续设计地表水中新兴药物污染物的去除策略提供了宝贵的信息。环境毒理化学2024；00：1–11。 © 2024 SETAC 版权所有