Myopia is a global public health issue. Rigid contact lenses (RCLs) are an effective way to correct or control myopia. However, bioadhesion issues remain one of the significant obstacles limiting its clinical application. Although enhancing hydrophilicity through various surface treatments can mitigate this problem, the duration of effectiveness is short-lived and the processing involved is complex and costly. Herein, an antiadhesive RCLs material was designed via 8-armed methacrylate-POSS (8MA-POSS), and poly(ethylene glycol) methacrylate (PEGMA) copolymerization with 3-[tris(trimethylsiloxy)silyl] propyl methacrylate (TRIS). The POSS and PEG segments incorporated P(TRIS-co-PEGMA-co-8MA-POSS) (PTPM) material was obtained and their optical transparency, refractive index, resolution, hardness, surface charge, thermal features, and wettability were tested and optimized. The antibioadhesion activities, including protein, lipid, and bacteria, were evaluated as well. In vitro and in vivo results indicated that the optimized antibioadhesive PTPM materials present good biocompatibility and biosafety. Thus, such POSS and PEG segments containing material were a potential antibioadhesive RCL material option.

中文翻译：

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含 POSS 和 PEG 的共聚物在抗生物粘附硬性隐形眼镜材料中的应用

近视是一个全球性的公共卫生问题。硬性隐形眼镜（RCL）是矫正或控制近视的有效方法。然而，生物粘附问题仍然是限制其临床应用的重大障碍之一。尽管通过各种表面处理增强亲水性可以缓解这个问题，但效果的持续时间很短，并且涉及的处理复杂且成本高昂。在此，通过八臂甲基丙烯酸酯-POSS（8MA-POSS）以及聚（乙二醇）甲基丙烯酸酯（PEGMA）与甲基丙烯酸3-[三（三甲基硅氧基）甲硅烷基]丙酯（TRIS）共聚设计了一种抗粘附RCL材料。获得了掺入 POSS 和 PEG 片段的 P(TRIS- co -PEGMA- co -8MA-POSS) (PTPM) 材料，并对其光学透明度、折射率、分辨率、硬度、表面电荷、热特性和润湿性进行了测试和优化。还评估了抗生物粘附活性，包括蛋白质、脂质和细菌。体外和体内结果表明，优化后的抗生物粘附PTPM材料具有良好的生物相容性和生物安全性。因此，此类含有 POSS 和 PEG 片段的材料是潜在的抗生物粘附 RCL 材料选择。