Abstract

Previous studies reported that iron may have an indispensable role in the risk of hypertension (HTN). However, the result of the studies on the relationship between iron and risk of HTN is inconsistent. This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case–control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94–0.99, P = 0.04). The association remained significant after adjustment for age, gender, smoking, drinking alcohol, calorie intake, and BMI (OR = 0.94, CI 95%: 0.89–0.98, P = 0.01). As a conclusion, iron intake was inversely associated with HTN. Further longitudinal studies on the effect of iron intake on BP are required to confirm this finding.

中文翻译：

---

铁摄入量与高血压的关系，铁摄入量会降低血压吗？

摘要

此前的研究报告称，铁可能在高血压（HTN）风险中发挥着不可或缺的作用。然而，关于铁与高血压风险之间关系的研究结果并不一致。本研究旨在评估伊朗人群膳食铁摄入量与高血压之间的关联。这项病例对照研究对伊朗 Sabzevar 的 4184 名 35 至 70 岁人群进行，其中包括 1239 名高血压患者和 2945 名血压正常 (BP) 患者。使用食物频率问卷（FFQ）评估膳食摄入量。营养师IV软件用于评估膳食铁摄入量。研究发现铁摄入量与 HTN 呈负相关（OR  = 0.97，CI 95%：0.94–0.99，P  = 0.04）。调整年龄、性别、吸烟、饮酒、卡路里摄入量和 BMI 后，这种关联仍然显着（OR  = 0.94，CI 95%：0.89–0.98，P  = 0.01）。结论是，铁摄入量与高血压呈负相关。需要进一步纵向研究铁摄入量对血压的影响来证实这一发现。