Background: Silene undulata is historically used for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties. background: Silene undulata has a historical use for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties. Objective: This study aimed to investigate the phytochemical composition of S. undulata through LC-MS/MS analysis and explore its potential serotonergic activity, which could support and confirm the traditional use of S. undulata as a dream-inducing plant. Methods: LC-MS/MS analysis was conducted on S. undulata extract, identifying 51 phytochemicals, including norharman, harmalol, harmaline, harmine, and ibogaine alkaloids. ADMET and Molecular docking investigations were employed to assess the serotonergic potential of these compounds. Results: The analysis revealed the presence of β-carboline alkaloids, such as norharman, harmalol, harmaline, harmine, and ibogaine, within S. undulata extract. ADMET analysis showed that these compounds have a favourable pharmacokinetic properties. In addition, molecular docking investigations showed that harmaline (-8.90 Kcal/mol), harmalol (-8.56 Kcal/mol), and ibogaine (-8.75 Kcal/mol) exhibited binding affinities comparable to the control molecule, LSD (-9.14 Kcal/mol), indicating potential agonistic activity at serotonin 5-HT2A receptor. Conclusion: These findings provide insights into the potential therapeutic benefits of S. undulata, supporting its traditional use as a psychoactive plant. This study investigated the chemical constituents and potential serotonergic agonist activity of S. undulata for the first time. While promising, further research is necessary to uncover additional medicinal properties associated with the identified phytochemical components.

中文翻译：

---

Silene undulata Aiton 精神活性成分的潜在血清素 5-HT2A 受体激动剂：LC-MS/MS、ADMET 和分子对接研究

背景：Silene undulata 历史上被用于诱发生动且具有预见性的清醒梦，但有关其植物化学成分和潜在药理学特性的信息有限。背景：Silene undulata 历史上曾用于诱发生动且具有预见性的清醒梦，但有关其植物化学成分和潜在药理学特性的信息有限。目的：本研究旨在通过 LC-MS/MS 分析研究波状海棠的植物化学成分，并探讨其潜在的 5-羟色胺活性，以支持和证实波状海棠作为引梦植物的传统用途。方法：对波状海棠提取物进行 LC-MS/MS 分析，鉴定出 51 种植物化学物质，包括去甲哈曼、哈马洛尔、骆驼蓬碱、骆驼蓬碱和伊博加因生物碱。采用 ADMET 和分子对接研究来评估这些化合物的血清素潜力。结果：分析表明，波叶草提取物中存在 β-咔啉生物碱，例如去甲哈曼、哈马洛、骆驼蓬碱、骆驼蓬碱和伊博加因。 ADMET 分析表明这些化合物具有良好的药代动力学特性。此外，分子对接研究表明，骆驼蓬碱（-8.90 Kcal/mol）、骆驼蓬醇（-8.56 Kcal/mol）和伊博加因（-8.75 Kcal/mol）表现出与对照分子LSD（-9.14 Kcal/mol）相当的结合亲和力。 mol)，表明对血清素 5-HT2A 受体具有潜在的激动活性。结论：这些发现为了解波状海藻的潜在治疗功效提供了见解，支持其作为精神活性植物的传统用途。本研究首次研究了波状S. undulata 的化学成分和潜在的血清素激动剂活性。虽然前景广阔，但还需要进一步研究来揭示与已确定的植物化学成分相关的其他药用特性。