Background: Due to the rarity of ovarian cancer diagnosed during pregnancy, the literature on the treatment of subtypes of epithelial ovarian cancer in pregnancy is sparse. The aim of our review was to analyze cases of high-grade serous ovarian cancer in pregnancy. Methods: The PubMed and Scopus databases were searched for relevant articles published in English between January 2000 and December 2023. The references of all the relevant reviews found were also checked to avoid omitting eligible studies. Information on the all retrieved cases was extracted and reviewed in detail. The most important detail was the subtype of high-grade serous ovarian cancer, which was referred to as serous adenocarcinoma (grade 2 or grade 3) in older cases. Results: We found eleven cases with relevant details of high-grade serous ovarian cancer diagnosed in pregnancy. Despite the small number of cases we found, our study demonstrated the importance of an accurate initial vaginal ultrasound at the first examination in pregnancy and the safety of diagnostic surgery and chemotherapy in pregnancy. Conclusions: There have not been long-term follow-ups of patients’ oncologic and obstetric outcomes. As patients should be comprehensively informed, more detailed case reports or series with longer follow-up periods are needed.

中文翻译：

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妊娠期高级别浆液性卵巢癌：从诊断到治疗

背景：由于妊娠期诊断出的卵巢癌很少见，关于妊娠期上皮性卵巢癌亚型治疗的文献很少。我们综述的目的是分析妊娠期高级别浆液性卵巢癌病例。方法：在 PubMed 和 Scopus 数据库中检索 2000 年 1 月至 2023 年 12 月期间以英文发表的相关文章。还检查了所有找到的相关综述的参考文献，以避免遗漏符合条件的研究。所有检索到的案例的信息均被提取并详细审查。最重要的细节是高级别浆液性卵巢癌的亚型，在老年病例中被称为浆液性腺癌（2 级或 3 级）。结果：我们发现了 11 例妊娠期诊断出的具有相关详细信息的高级别浆液性卵巢癌病例。尽管我们发现的病例数量很少，但我们的研究证明了在妊娠期第一次检查时进行准确的初始阴道超声检查的重要性以及妊娠期诊断性手术和化疗的安全性。结论：尚未对患者的肿瘤学和产科结果进行长期随访。由于应全面告知患者，因此需要更详细的病例报告或更长随访期的系列报告。