Rosa laevigata Michx. polysaccharides (RLP) have been demonstrated to possess antioxidant and anti‐inflammatory properties. However, the mechanisms and efficacy of these polysaccharide components in preventing ulcerative colitis (UC) remain to be elucidated. The efficacy and mechanisms of RLP were investigated in a study that utilized healthy adult beagles to establish a UC model, considering the similarities in gut microbiota between humans and dogs. In the study, the beagle model induced by sodium dextran sulfate exhibited typical symptoms of ulcerative colitis, such as weight loss and diarrhea. All these symptoms and changes were significantly ameliorated through oral supplementation of RLP. Additionally, microbial community analysis based on the 16S rDNA gene revealed that RLP alleviated UC by increasing the abundance of beneficial bacteria and reducing the abundance of harmful bacteria. In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.

中文翻译：

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金樱子多糖通过调节肠道菌群改善硫酸葡聚糖钠诱导的比格犬溃疡性结肠炎

金樱子Michx。多糖（RLP）已被证明具有抗氧化和抗炎特性。然而，这些多糖成分预防溃疡性结肠炎（UC）的机制和功效仍有待阐明。考虑到人类和狗肠道微生物群的相似性，一项利用健康成年比格犬建立 UC 模型的研究调查了 RLP 的功效和机制。研究中，右旋糖酐硫酸钠诱导的比格犬模型表现出典型的溃疡性结肠炎症状，如体重减轻、腹泻等。通过口服补充 RLP，所有这些症状和变化均得到显着改善。此外，基于 16S rDNA 基因的微生物群落分析表明，RLP 通过增加有益细菌的丰度和减少有害细菌的丰度来缓解 UC。总之，我们的研究表明，RLP 通过保护肠道屏障和调节肠道微生物群组成，有效缓解结肠炎。