Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines.

中文翻译：

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LPS 焕然一新

细胞内脂多糖 (LPS) 的检测会激活由非典型炎症小体引发的免疫反应。 ATGL 现已被确定为该通路的负调节因子，通过去除 LPS 的酰基链来抑制炎症，从而防止炎症性半胱天冬酶和细胞因子的激活。