Magnetic nano ferrites (MNFs) can arbitrate applied magnetic fields to generate the magnetic force effects and local magnetic fields, which are beneficial for biomedical applications. Spinel nano ferrites have been extensively used for biomedical applications because of their extraordinary nano-magnetism properties. The current work aims to prepare and analyse spinel nano ferrites (SNFs) for cancer cell treatment in biomedical applications. The biocompatibility of the (SNFs) would be improved by functionalizing with an anti-cancer drug. The current work reports the synthesis, structural, spectral, morphological, and electromagnetic evaluations of the Gd doped Co nano ferrites (GCF) having the composition of CoFeGdO (x = 0.0, 0.025, 0.05, and 0.075). The nano ferrites of GCF were synthesized using the sol-gel method. The characterizations were carried out using XRD, FESEM, TEM, UV–Vis, and FTIR respectively. XRD reveals a single-phase cubic phase of Co ferrites, whereas Gd-doped shows extra peaks of GdFeO. VNA and VSM to find GCF nano ferrites' dielectric and magnetic features. FESEM and TEM images confirm the spherical and hexagon-shaped nanoparticles. The low coercivity with high magnetization was investigated for Co ferrites rather than Gd doped Co nano ferrites. GCF particles were functionalized with an anti-cancer drug (5-Fluorouracil (FU)) to investigate the cytotoxicity and cell viability against a human breast cancer cell line (MFC-7). Cytotoxicity study of Gd substituted Co ferrites (GCF) was also evaluated. The present results depicted that 5-FU-coated GCF particles were more toxic and killed almost 21–66% of cancer cells. It is expected that the Co nano ferrites will be found to be less harmful and suitable for cancer cell treatment in biomedical applications.

中文翻译：

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氟尿嘧啶修饰的掺钆钴纳米铁氧体的磁电、物理化学和细胞毒性评价

磁性纳米铁氧体（MNF）可以仲裁施加的磁场以产生磁力效应和局部磁场，这有利于生物医学应用。尖晶石纳米铁氧体因其非凡的纳米磁性而被广泛用于生物医学应用。目前的工作旨在制备和分析尖晶石纳米铁氧体（SNF），用于生物医学应用中的癌细胞治疗。 (SNF) 的生物相容性将通过抗癌药物的功能化得到改善。目前的工作报告了具有 CoFeGdO（x = 0.0、0.025、0.05 和 0.075）成分的 Gd 掺杂 Co 纳米铁氧体（GCF）的合成、结构、光谱、形态和电磁评估。采用溶胶-凝胶法合成了GCF纳米铁氧体。分别使用 XRD、FESEM、TEM、UV-Vis 和 FTIR 进行表征。 XRD 显示出 Co 铁氧体的单相立方相，而掺 Gd 则显示出 GdFeO 的额外峰。 VNA 和 VSM 用于查找 GCF 纳米铁氧体的介电和磁性特性。 FESEM 和 TEM 图像证实了球形和六边形纳米颗粒。研究了钴铁氧体而不是掺钆钴纳米铁氧体的低矫顽力和高磁化强度。 GCF 颗粒用抗癌药物（5-氟尿嘧啶 (FU)）进行功能化，以研究针对人乳腺癌细胞系 (MFC-7) 的细胞毒性和细胞活力。还评估了钆取代钴铁氧体 (GCF) 的细胞毒性研究。目前的结果表明，5-FU 涂层的 GCF 颗粒毒性更大，可以杀死几乎 21-66% 的癌细胞。预计钴纳米铁氧体危害较小，适合生物医学应用中的癌细胞治疗。