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High-efficient anticancer, antibacterial, and adsorption activities of 1T/2H MoS2 nanoflowers decorated by Fe3O4 and Ag nanoparticles
Materials Chemistry and Physics ( IF 4.6 ) Pub Date : 2024-03-27 , DOI: 10.1016/j.matchemphys.2024.129252
Farzad Sadeghi , Mohsen Ghasemi , Vishtasb Soleimanian , Hossein Abbastabar Ahangar

In this research, the 1T/2H MoS/FeO/Ag ternary nanocomposite was fabricated, and its features were compared with MoS. Characterization was carried out by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray, Fourier transform infrared spectroscopy, UV–visible spectroscopy, vibrating sample magnetometry, and Zeta potential analysis. Adsorption, antibacterial, and anticancer activities were also studied for this nanocomposite. To find the best removal efficiency of methylene blue adsorption under ultrasonic conditions were examined at three levels of pH (5, 7, and 9), methylene blue concentration (5, 10, and 20 ppm), nanocomposite dosage (2, 4, and 6 mg), and ultrasonic time (3, 6, and 12 min) using the L9 (3^4) orthogonal array of Taguchi's method in design of experiment. 97% removal efficiency was found at 5, 20 ppm, 2 mg, and 3 min for pH, methylene blue concentration, nanocomposite dosage, and ultrasonic time, respectively. Additionally, in-vitro studies of antibacterial activity (for and ) and cytotoxicity (for HCT-116 and NIH-3T3 cell lines) of the nanocomposite were studied. The half minimum inhibitory concentration of and were calculated at 13.09 and 49.54 , respectively. The half-maximal inhibitory concentration of the HCT-116 was obtained at 57.16 and 42.52 for 24 and 48 h, respectively.

中文翻译:

Fe3O4和Ag纳米粒子修饰的1T/2H MoS2纳米花的高效抗癌、抗菌和吸附活性

本研究制备了1T/2H MoS2/FeO/Ag三元纳米复合材料,并与MoS2进行了性能比较。通过 X 射线衍射、扫描电子显微镜、能量色散 X 射线、傅里叶变换红外光谱、紫外可见光谱、振动样品磁力测定和 Zeta 电位分析进行表征。还研究了这种纳米复合材料的吸附、抗菌和抗癌活性。为了找到超声条件下亚甲基蓝吸附的最佳去除效率,在 pH 值(5、7 和 9)、亚甲基蓝浓度(5、10 和 20 ppm)、纳米复合材料剂量(2、4 和 4)三个水平下进行了检测。 6 mg),超声时间(3、6、12 分钟)在实验设计中使用田口方法的 L9(3^4)正交阵列。 pH 值、亚甲蓝浓度、纳米复合材料剂量和超声时间分别在 5、20 ppm、2 mg 和 3 分钟时去除效率为 97%。此外,还对纳米复合材料的抗菌活性(针对 和 )和细胞毒性(针对 HCT-116 和 NIH-3T3 细胞系)进行了体外研究。计算出的半数最小抑制浓度分别为13.09和49.54。 HCT-116 24 小时和 48 小时的半最大抑制浓度分别为 57.16 和 42.52。
更新日期:2024-03-27
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