The use of disinfectants, such as Sodium Dodecylbenzene Sulfonic acid salt (SDBS), has grown since the SARS-CoV-2 pandemic, with environmentally unknown consequences. The present study analyzed SDBS effects in the fish species , using a combination of biomarkers. Our data reported that larvae had their total locomotor activity increased when exposed to 1 mg/L of SDBS, but this parameter was decreased in fish exposed to 5 mg/L. A significant increment of erratic movements was reported in fish exposed to 1 and 5 mg/L of SDBS. These concentrations inhibited CYP1A1/CYP1A2, and of GSTs inhibition, suggesting SDBS is not preferentially biotransformed by these routes. Results concerning the antioxidant defense biomarkers (CAT and GPx) showed no straightforward pattern, suggesting SDBS exposure may have resulted in changes in redox balance. Finally, acetylcholinesterase activity increased. In summary, increased use of SDBS in a near future may result in deleterious effects in environmentally exposed fish.

中文翻译：

---

SARS-CoV-2 大流行中消毒剂 SDBS 对斑马鱼的生物反应

自 SARS-CoV-2 大流行以来，十二烷基苯磺酸钠 (SDBS) 等消毒剂的使用有所增加，对环境造成的后果未知。本研究使用生物标志物组合分析了 SDBS 对鱼类的影响。我们的数据表明，当暴露于 1 mg/L 的 SDBS 时，幼虫的总运动活性增加，但暴露于 5 mg/L 的鱼中该参数下降。据报道，暴露于 1 毫克/升和 5 毫克/升 SDBS 的鱼的不稳定运动显着增加。这些浓度抑制 CYP1A1/CYP1A2 和 GST 抑制，表明 SDBS 不优先通过这些途径进行生物转化。关于抗氧化防御生物标志物（CAT 和 GPx）的结果没有显示出直接的模式，表明 SDBS 暴露可能导致氧化还原平衡的变化。最后，乙酰胆碱酯酶活性增加。总之，在不久的将来，SDBS 的使用增加可能会对暴露在环境中的鱼类产生有害影响。