Fibroblast growth factor 21 (FGF21) is a secreted protein that plays an important role in atherosclerosis and pathological cardiac remodeling. However, the correlation between FGF21 and the degree of coronary artery stenosis and its potential role in acute myocardial infarction (AMI) remain unclear. We examined whether changes in FGF21 levels in AMI correlate with the degree of coronary artery stenosis and the levels of inflammatory factors, and preliminarily investigated the effects of FGF21 on inflammatory factor levels and myocardial injury in rats with AMI. Serum levels of FGF21 and inflammatory factors in the AMI group and control group were measured, and the correlation between FGF21 and clinical indicators and inflammatory factors was analyzed. The effects of FGF21 on cardiac function and inflammatory response were evaluated through echocardiography and measurement of inflammatory factors. Multivariate logistic regression analysis showed that neutrophil percentage (NEUT%, odds ratio [OR]: 1.232; 95 % confidence interval [CI]: 1.028–1.477; = 0.024) and FGF21 levels (OR: 2.063; 95 % CI: 1.187–3.586; = 0.01) had independent effects on AMI. Spearman's rank correlation test showed that FGF21 levels were positively correlated with leukocyte count, NEUT%, neutrophil count, neutrophil to lymphocyte ratio, C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP-1) and Gensini scores ( < 0.01), but negatively correlated with lymphocyte count ( < 0.01). FGF21 levels in myocardial tissues and serum levels of FGF21, IL-6, TNF-a, and MCP-1 were significantly higher in AMI rats than in the sham-operated group ( < 0.01). After overexpression of FGF21, serum levels of IL-6, TNF-a, and MCP-1 in rats were significantly decreased ( < 0.01), and cardiac function improved significantly. FGF21 levels were independently associated with AMI and may be related to the severity of coronary artery stenosis. Overexpression of FGF21 reduced serum inflammatory factor levels and improved cardiac function in AMI rats.

中文翻译：

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急性心肌梗死患者循环成纤维细胞生长因子21水平与炎症因子及冠状动脉狭窄程度的相关性

成纤维细胞生长因子 21 (FGF21) 是一种分泌蛋白，在动脉粥样硬化和病理性心脏重塑中发挥重要作用。然而，FGF21与冠状动脉狭窄程度之间的相关性及其在急性心肌梗死（AMI）中的潜在作用仍不清楚。我们探讨AMI中FGF21水平的变化是否与冠状动脉狭窄程度和炎症因子水平相关，并初步探讨FGF21对AMI大鼠炎症因子水平和心肌损伤的影响。测定AMI组和对照组血清中FGF21、炎症因子的含量,分析FGF21与临床指标、炎症因子的相关性。通过超声心动图和炎症因子测量评估FGF21对心功能和炎症反应的影响。多变量逻辑回归分析显示，中性粒细胞百分比（NEUT%，比值比 [OR]：1.232；95% 置信区间 [CI]：1.028–1.477；= 0.024）和 FGF21 水平（OR：2.063；95% CI：1.187–3.586） ; = 0.01) 对 AMI 有独立影响。 Spearman等级相关检验显示，FGF21水平与白细胞计数、NEUT%、中性粒细胞计数、中性粒细胞与淋巴细胞比值、C反应蛋白、白介素6（IL-6）、肿瘤坏死因子-α（TNF-α）呈正相关。 、单核细胞趋化蛋白-1 (MCP-1) 和 Gensini 评分 ( < 0.01)，但与淋巴细胞计数呈负相关 ( < 0.01)。 AMI 大鼠心肌组织中 FGF21 水平以及血清 FGF21、IL-6、TNF-a、MCP-1 水平显着高于假手术组（ < 0.01）。 FGF21过表达后，大鼠血清IL-6、TNF-a、MCP-1水平显着降低（<0.01），心功能显着改善。 FGF21 水平与 AMI 独立相关，并且可能与冠状动脉狭窄的严重程度相关。 FGF21 的过表达可降低 AMI 大鼠的血清炎症因子水平并改善心功能。