当前位置：
X-MOL 学术
›
Epilepsy Behav.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association between serum apolipoprotein E and cognitive function in Chinese patients with temporal lobe epilepsy
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2024-03-28 , DOI: 10.1016/j.yebeh.2024.109750 Yuwei Han , Guangzhi Hao , Zhen Wang , Chenchen Wang , Xin Qi , Guobiao Liang , Xiaoming Li
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2024-03-28 , DOI: 10.1016/j.yebeh.2024.109750 Yuwei Han , Guangzhi Hao , Zhen Wang , Chenchen Wang , Xin Qi , Guobiao Liang , Xiaoming Li
To investigate the effect of serum apolipoprotein E (APOE) levels on cognitive function in patients with temporal lobe epilepsy (TLE). Clinical data were collected from 190 subjects including 110 TLE patients and 80 healthy people. Cognitive function was assessed using the Addenbrooke’s Cognitive Examination Revised (ACE-R) scale. Serum levels of APOE were measured using ELISA kits. Genotyping of APOE in peripheral blood was detected by microarray hybridization. Patients with TLE had significantly lower ACE-R total score, memory and verbal fluency scores compared to the healthy group. Serum levels of APOE were significantly higher in TLE patients than in the healthy subjects. Serum APOE levels were significantly negatively correlated with ACE-R total score, memory and verbal fluency scores. The cognitive function score of TLE with APOE 4 allele was lower than that of TLE without APOE 4 allele. Our study showed that serum APOE levels were higher in TLE patients than in the healthy population. And serum APOE levels were associated with cognitive dysfunction in TLE patients. APOE 4 allele carriers have poor cognitive function in TLE patients.
更新日期：2024-03-28
京公网安备 11010802027423号