Age at menarche, reproductive lifespan, and age at menopause are associated with several cardiovascular diseases, but their relationship with atrial fibrillation (AF) is uncertain. We linked information on all women who participated in the third survey of the population-based, longitudinal HUNT study in Norway with medical records from all local hospitals. A total of 14,632 women aged 60 or more were followed for validated incident AF. We retrieved age at menarche and age at menopause from the HUNT questionnaires. Reproductive lifespan was defined as the difference between age at menarche and age at menopause. We used Cox proportional hazards regression models to assess associations between AF and age at menarche, reproductive lifespan, and age at menopause. During a median follow-up of 8.17 years (136,494 person-years), 1217 (8.3 %) participants developed AF. In multivariable-adjusted analyses, we observed no associations between early or late age at menarche and AF (hazard ratios (HRs): <12 years: 0.85 [95 % confidence interval (CI), 0.65–1.12]; ≥16 years: 0.99 [95 % CI, 0.80–1.24] compared to those who attained menarche at 13–14 years). The HR for a reproductive lifespan shorter than 30 years was 0.91 [95 % CI, 0.72–1.15] compared to 34–37 years. Likewise, there was no clear association between premature or early age at menopause and AF (HRs: <40 years: 1.21 [95 % CI, 0.83–1.75]; 40–44 years: 0.97 [95 % CI, 0.77–1.22] compared to 50–54 years). In this population of women aged 60 years and over, the risk of AF was not associated with age at menarche, reproductive lifespan, or age at menopause.

中文翻译：

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初潮年龄、生育寿命和绝经年龄与心房颤动风险的关系：HUNT 研究

初潮年龄、生育寿命和绝经年龄与多种心血管疾病相关，但它们与心房颤动 (AF) 的关系尚不确定。我们将参与挪威第三次基于人群的纵向 HUNT 研究的所有女性的信息与所有当地医院的医疗记录联系起来。共有 14,632 名 60 岁或以上的女性接受了经过验证的 AF 事件跟踪。我们从 HUNT 问卷中检索初潮年龄和绝经年龄。生殖寿命定义为初潮年龄与绝经年龄之间的差值。我们使用 Cox 比例风险回归模型来评估 AF 与初潮年龄、生殖寿命和绝经年龄之间的关联。在中位随访 8.17 年（136,494 人年）期间，1217 名（8.3%）参与者出现了 AF。在多变量调整分析中，我们观察到初潮年龄早或晚与 AF 之间没有关联（风险比 (HR)：<12 岁：0.85 [95% 置信区间 (CI)，0.65–1.12]；≥16 岁：0.99 [95% CI, 0.80–1.24] 与那些在 13–14 岁时初潮的人相比）。与 34-37 岁相比，生殖寿命短于 30 岁的 HR 为 0.91 [95% CI，0.72-1.15]。同样，过早或过早绝经与房颤之间也没有明显关联（HR：<40 岁：1.21 [95 % CI，0.83–1.75]；40–44 岁：0.97 [95 % CI，0.77–1.22]至 50-54 岁）。在 60 岁及以上的女性人群中，房颤风险与初潮年龄、生育寿命或绝经年龄无关。