PurposeAlthough the adverse effects of atrial fibrillation (AF) on cancers have been well reported, the relationship between the AF and the adverse outcomes in prostate cancer (PC) remains inconclusive. This study aimed to explore the prevalence of AF and evaluate the relationship between AF and clinical outcomes in PC patients.MethodsPatients diagnosed with PC between 2008 and 2017 were identified from the National Inpatient Sample database. The trends in AF prevalence were compared among PC patients and their subgroups. Multivariable regression models were used to assess the associations between AF and in-hospital mortality, length of hospital stay, total cost, and other clinical outcomes.Results256,239 PC hospitalizations were identified; 41,356 (83.8%) had no AF and 214,883 (16.2%) had AF. AF prevalence increased from 14.0% in 2008 to 20.1% in 2017 (P < .001). In-hospital mortality in PC inpatients with AF increased from 5.1% in 2008 to 8.1% in 2017 (P < .001). AF was associated with adverse clinical outcomes, such as in-hospital mortality, congestive heart failure, pulmonary circulation disorders, renal failure, fluid and electrolyte disorders, cardiogenic shock, higher total cost, and longer length of hospital stay.ConclusionsThe prevalence of AF among inpatients with PC increased from 2008 to 2017. AF was associated with poor prognosis and higher health resource utilization. Better management strategies for patients with comorbid PC and AF, particularly in older individuals, are required.

中文翻译：

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前列腺癌患者心房颤动的患病率和结果：美国的一项全国性分析

目的尽管心房颤动 (AF) 对癌症的不良影响已得到充分报道，但 AF 与前列腺癌 (PC) 不良结果之间的关系仍无定论。本研究旨在探讨 PC 患者 AF 的患病率并评估 AF 与临床结果之间的关系。方法从国家住院患者样本数据库中识别 2008 年至 2017 年诊断为 PC 的患者。比较了 PC 患者及其亚组中 AF 患病率的趋势。使用多变量回归模型评估 AF 与院内死亡率、住院时间、总费用和其他临床结果之间的关联。结果 256,239 例 PC 住院治疗被确定； 41,356 人 (83.8%) 没有房颤，214,883 人 (16.2%) 患有房颤。 AF 患病率从 2008 年的 14.0% 上升至 2017 年的 20.1% (P < .001)。患有 AF 的 PC 住院患者的院内死亡率从 2008 年的 5.1% 上升至 2017 年的 8.1% (P < .001)。房颤与不良临床结局相关，如院内死亡率、充血性心力衰竭、肺循环障碍、肾功能衰竭、液体和电解质紊乱、心源性休克、较高的总费用和较长的住院时间。 结论2008 年至 2017 年，患有 PC 的住院患者有所增加。房颤与预后不良和较高的卫生资源利用率相关。对于患有 PC 和 AF 的患者，特别是老年人，需要更好的管理策略。