The high prevalence of obesity in Mexico starting from the early stages of life is concerning and represents a major public health problem. Genetic association studies have reported that single nucleotide variants (SNVs) in SIRT1, an NAD+-dependent deacetylase that plays an important role in the regulation of metabolic cellular functions, are associated with multiple metabolic disorders and the risk of obesity. In the present study, we analyzed the effect that the SNVs rs1467568 and rs7895833 of the SIRT1 gene may have on cardiometabolic risk factors in a young adult population from Mexico. A cross-sectional study was carried out with young adults between the ages of 18 and 25 who had a body mass index (BMI) greater than 18.5 kg/m2. This study included 1122 young adults who were classified into the normal weight (n = 731), overweight group (n = 277), and obesity group (n = 114) according to BMI of whom 405 and 404 volunteers were genotyped for rs1467568 and rs7895833 respectively using TaqMan probes through allelic discrimination assays. We found that the male sex carrying the G allele of rs7895833 had slightly lower BMI levels (p = 0.009). Furthermore, subjects carrying rs1467568 (G allele) showed a 34% lower probability of presenting with hyperbetalipoproteinemia where female carrying rs1467568 had lower levels of total cholesterol (p = 0.030), triglycerides (p = 0.026) and LDL cholesterol (p = 0.013). In conclusion, these findings suggest that the presence of both SNVs could have a non-risk effect against dyslipidemia in the Mexican population.

中文翻译：

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墨西哥年轻人 SIRT1 基因变异分析：与超重和肥胖的关系

墨西哥从生命早期阶段就开始出现肥胖症，这一现象令人担忧，也是一个重大的公共卫生问题。遗传关联研究报告称，SIRT1（一种 NAD+ 依赖性脱乙酰酶，在代谢细胞功能的调节中发挥重要作用）中的单核苷酸变异 (SNV) 与多种代谢紊乱和肥胖风险相关。在本研究中，我们分析了 SIRT1 基因的 SNV rs1467568 和 rs7895833 对墨西哥年轻成年人群心脏代谢危险因素的影响。对年龄在 18 岁至 25 岁之间、体重指数 (BMI) 大于 18.5 kg/m2 的年轻人进行了一项横断面研究。本研究纳入了 1122 名年轻人，根据 BMI 将其分为正常体重组（n = 731）、超重组（n = 277）和肥胖组（n = 114），其中 405 名和 404 名志愿者进行了 rs1467568 和 rs7895833 基因分型分别使用 TaqMan 探针通过等位基因区分测定。我们发现携带 rs7895833 G 等位基因的男性的 BMI 水平略低 (p = 0.009)。此外，携带 rs1467568（G 等位基因）的受试者表现出高 β 脂蛋白血症的可能性降低 34%，其中携带 rs1467568 的女性总胆固醇（p = 0.030）、甘油三酯（p = 0.026）和 LDL 胆固醇（p = 0.013）水平较低。总之，这些发现表明，这两种 SNV 的存在可能对墨西哥人群的血脂异常产生非风险影响。