RORα is a transcription factor encoded by RORA gene. This protein is involved in several metabolic conditions, including obesity. We assessed association between two polymorphisms within this gene (namely rs11639084 and rs4774388) and severe obesity in Iranian population. Both SNPs were associated with obesity in all models (P < 0.0001) except for over-dominant model. T allele of rs11639084 was associated with this trait with OR (95% CI) of 16.85 (13.11–21.67) and was considered as the risk allele. Allelic model best fit the data, since the AIC value for this model was the highest (AIC = 28.82). In the co-dominant model, TT genotype was associated with obesity with OR (95% CI) of 301.6 (137.4–662.1). This genotype was shown to be the risk genotype in the recessive model when compared with TC+CC (OR (95% CI) = 60.54 (30.35–120.7)). The C allele of rs4774388 was shown to be the risk allele with OR (95% CI) of 4.61 (3.72–5.71). In the recessive model, the CC genotype was associated with the mentioned trait with OR (95% CI) of 9.92 (6.62–14.8). This model best fit the data (AIC = 37.08). Cumulatively, the current study suggests contribution of RORα to the pathogenesis of obesity.

RORα是由RORA基因编码的转录因子。这种蛋白质与多种代谢状况有关，包括肥胖。我们评估了该基因内的两个多态性（即 rs11639084 和 rs4774388）与伊朗人群严重肥胖之间的关联。 除过度显性模型外，这两个 SNP 均与所有模型中的肥胖相关（P < 0.0001）。 rs11639084 的 T 等位基因与此性状相关，OR (95% CI) 为 16.85 (13.11–21.67)，被认为是风险等位基因。等位基因模型最适合数据，因为该模型的 AIC 值最高 (AIC = 28.82)。在共显性模型中，TT 基因型与肥胖相关，OR (95% CI) 为 301.6 (137.4–662.1)。与 TC+CC 相比，该基因型被证明是隐性模型中的风险基因型（OR (95% CI) = 60.54 (30.35–120.7)）。 rs4774388 的 C 等位基因被证明是风险等位基因，OR (95% CI) 为 4.61 (3.72–5.71)。在隐性模型中，CC 基因型与上述性状相关，OR (95% CI) 为 9.92 (6.62–14.8)。该模型最适合数据 (AIC = 37.08)。总的来说，目前的研究表明 RORα 对肥胖发病机制的贡献。