Abstract

Purpose of Review

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age. It has been associated with metabolic, reproductive, and psychiatric disorders. Despite its association with insulin resistance (IR) and cardiovascular disease (CVD) risk factors, the association between PCOS and CVD outcomes has been conflicting. This review reports the updated evidence between PCOS, insulin resistance, and CVD events.

Recent Findings

IR is highly prevalent occurring in 50 to 95% of general and obese PCOS women. The etiology of PCOS involves IR and hyperandrogenism, which lead to CVD risk factors, subclinical CVD, and CVD outcomes. Multiple studies including meta-analysis confirmed a strong association between PCOS and CVD events including ischemic heart disease, stroke, atrial fibrillation, and diabetes, particularly among premenopausal women, and these associations were mediated by metabolic abnormalities.

Summary

PCOS is highly familial and has substantial CVD risk and transgenerational effects regardless of obesity. A personalized approach to the CVD risk assessment and management of symptom manifestations should be conducted according to its phenotypes. Lifestyle modifications and reduction in environmental stressors should be encouraged for CVD prevention among PCOS women.

中文翻译：

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多囊卵巢综合症、胰岛素抵抗和心血管疾病

摘要

审查目的

多囊卵巢综合症（PCOS）是育龄妇女中常见的内分泌疾病。它与代谢、生殖和精神疾病有关。尽管 PCOS 与胰岛素抵抗 (IR) 和心血管疾病 (CVD) 危险因素相关，但 PCOS 与 CVD 结果之间的关联一直是相互矛盾的。本综述报告了 PCOS、胰岛素抵抗和 CVD 事件之间的最新证据。

最近的发现

IR 在 50% 至 95% 的普通和肥胖 PCOS 女性中非常普遍。 PCOS 的病因涉及 IR 和高雄激素血症，这会导致 CVD 危险因素、亚临床 CVD 和 CVD 结果。包括荟萃分析在内的多项研究证实，PCOS 与 CVD 事件（包括缺血性心脏病、中风、心房颤动和糖尿病）之间存在密切关联，特别是在绝经前女性中，而这些关联是由代谢异常介导的。

概括

PCOS 具有高度家族性，无论是否肥胖，都具有显着的 CVD 风险和跨代影响。应根据其表型采取个性化的CVD风险评估和症状表现管理方法。应鼓励改变生活方式和减少环境压力，以预防 PCOS 女性的 CVD。