The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological diseases are associated with the differentiation of the proinflammatory T cell subset TH17 and its balance with the production of Treg. Recently, long non-coding RNAs (lncRNAs) have become important regulatory molecules in a wide range of illnesses. During epigenetic regulation, they can control the expression of important genes at several levels by affecting transcription, post-transcriptional actions, translation, and protein modification. They might connect with different molecules, such as proteins, DNA and RNA, and their structural composition is intricate. Because lncRNAs regulatebiological processes, including cell division, death, and growth, they are linked to severaldiseases. A notable instance of this is the lncRNA NEAT1, which has been the subject of several investigations to ascertain its function in immune cell development. In the context of immune cell development, several additional lncRNAs have been connected to Treg cell differentiation. In this work, we summarize current findings about the diverse functions of lncRNAs in Treg cell differentiation and control of the Th17/Treg homeostasis in autoimmune disorders, cancers, as well as several gynecological diseases where Tregs are key players.

中文翻译：

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LncRNA 通过调节 T 调节细胞参与免疫相关疾病的发病机制，最新综述

包括癌症和自身免疫性疾病在内的多种疾病的病理生理学取决于人类调节性 T 细胞 (Treg)，这些细胞的异常可能会引发这些疾病。癌症、自身免疫性疾病和妇科疾病与促炎性 T 细胞亚群 TH17 的分化及其与 Treg 产生的平衡有关。近年来，长链非编码RNA（lncRNA）已成为多种疾病的重要调节分子。在表观遗传调控过程中，它们可以通过影响转录、转录后作用、翻译和蛋白质修饰来在多个水平上控制重要基因的表达。它们可能与不同的分子连接，例如蛋白质、DNA和RNA，并且它们的结构组成非常复杂。由于 lncRNA 调节生物过程，包括细胞分裂、死亡和生长，因此它们与多种疾病有关。一个值得注意的例子是 lncRNA NEAT1，它已成为多项研究的主题，以确定其在免疫细胞发育中的功能。在免疫细胞发育的背景下，一些额外的 lncRNA 已与 Treg 细胞分化相关。在这项工作中，我们总结了有关lncRNA在Treg细胞分化中的多种功能以及在自身免疫性疾病、癌症以及Tregs起关键作用的几种妇科疾病中控制Th17/Treg稳态的最新研究结果。