The Virtual Child,Cancer Discovery

当前位置： X-MOL 学术 › Cancer Discov. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The Virtual Child
Cancer Discovery ( IF 28.2 ) Pub Date : 2024-04-04 , DOI: 10.1158/2159-8290.cd-23-1500
Richard J. Gilbertson _{1,

2} , Sam Behjati _{3,

4,

5} , Anna-Lisa Böttcher _{6,

7} , Marianne E. Bronner ₈ , Matthew Burridge ₉ , Henrick Clausing ₁₀ , Harry Clifford ₁₁ , Tracey Danaher ₁₂ , Laura K. Donovan ₁₃ , Jarno Drost _{14,

15} , Alexander M.M. Eggermont ₁₄ , Chris Emerson ₁₁ , Mona G. Flores ₁₆ , Petra Hamerlik ₁₇ , Nada Jabado ₁₈ , Andrew Jones ₉ , Henrick Kaessmann ₁₉ , Claudia L. Kleinman _{20,

21} , Marcel Kool _{6,

7,

14} , Lena M. Kutscher _{6,

22} , Gavin Lindberg ₂₃ , Emily Linnane _{1,

2} , John C. Marioni _{1,

3,

24} , John M. Maris _{25,

26} , Michelle Monje ₂₇ , Alexandra Macaskill ₂₈ , Steven Niederer ₂₉ , Paul A. Northcott ₃₀ , Elizabeth Peeters ₃₁ , Willemijn Plieger-van Solkema ₃₂ , Liane Preußner ₃₃ , Anne C. Rios ₁₄ , Karsten Rippe ₃₄ , Peter Sandford ₉ , Nikolaos G. Sgourakis _{26,

35} , Adam Shlien ₃₆ , Pete Smith ₃₇ , Karin Straathof _{38,

39} , Patrick J. Sullivan ₄₀ , Mario L. Suvà _{41,

42} , Michael D. Taylor ₄₃ , Emma Thompson ₄₄ , Roser Vento-Tormo ₃ , Brandon J. Wainwright ₄₅ , Robert J. Wechsler-Reya ₄₆ , Frank Westermann _{6,

47} , Shannon Winslade ₄₄ , Bissan Al-Lazikani ₄₈ , Stefan M. Pfister _{6,

7}

Affiliation

1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
2Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
3Wellcome Sanger Institute, Hinxton, United Kingdom.
4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
5Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
6Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
7Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
8Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
9Amazon Web Services, London, United Kingdom.
10SELECT SouthWest, Germany.
11NVIDIA, Cambridge, United Kingdom.
12Children's Cancer Foundation, Australia.
13University College London Great Ormond Street Institute of Child Health, United Kingdom.
14Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
15Oncode Institute, Utrecht, the Netherlands.
16NVIDIA, Santa Clara, California.
17University of Manchester, Manchester, United Kingdom.
18Department of Paediatrics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
19Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
20Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.
21Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
22Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
23The EVAN Foundation, Maryland.
24European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
25Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
26Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
27Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
28AstraZeneca, Oncology R&D, Cambridge, United Kingdom.
29Turing Research and Innovation Cluster in Digital Twins (TRIC: DT), The Alan Turing Institute, London, United Kingdom.
30Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee.
31b.r.a.i.n.child, SickKids Hospital, Toronto, Ontario, Canada.
32Dutch Childhood Cancer Organization (VKKN), the Netherlands.
33BioNTech SE, Mainz, Germany.
34German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany.
35Department of Pathology and Lab Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
36Genetics and Genomics Program, The Hospital for Sick Children, Toronto, Canada.
37Hula Therapeutics, Philadelphia, Pennsylvania.
38University College London Cancer Institute, London, United Kingdom.
39Great Ormond Street Hospital for Children, London, United Kingdom.
40Team Finn Foundation, Vancouver, British Columbia, Canada.
41Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
42Broad Institute of MIT and Harvard, Boston, Massachusetts.
43Texas Children's Cancer Center, Hematology-Oncology Section and Department of Pediatrics - Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, Texas.
44Brain Tumour Charity, Fleet, United Kingdom.
45The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.
46Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
47Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
48Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Summary: We are building the world's first Virtual Child–a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will “develop cancer” that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.

中文翻译：