Abstract

Purpose

Hypoparathyroidism is defined by hypocalcemia with inappropriately normal or low parathyroid hormone levels. The current standard treatment consists of lifelong calcium and/ or vitamin D supplementation. Even while on stable treatment regimens, hypoparathyroid patients might still suffer from symptoms that can negatively impact their quality of life.

Methods

A systematic literature review to identify the current knowledge regarding quality of life in patients with hypoparathyroidism receiving standard treatment was performed on November 1st, 2023. PubMed as well as Web of Science were searched. The systematic review is registered in PROSPERO (#CRD42023470924).

Results

After removal of duplicates, 398 studies remained for title and abstract screening, after which 30 were included for full-text screening. After exclusion of seven studies with five studies lacking a control population, one using a non-validated questionnaire, and one being a subsample of the larger included study, 23 studies were included in this systematic review. The majority of the included studies used a guideline-conform definition of hypoparathyroidism, and the SF-36 was the most often applied tool. Almost all studies (87%) reported statistically significantly lower scores in at least one quality of life domain compared to a norm population or controls.

Conclusion

Patients with hypoparathyroidism receiving standard treatment report impairments in quality of life. The reasons for these impairments are probably multifaceted, making regular monitoring and the inclusion of various professionals necessary.

中文翻译：

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接受标准治疗的甲状旁腺功能减退症患者的生活质量：更新的系统评价

摘要

目的

甲状旁腺功能减退症是指低钙血症伴甲状旁腺激素水平异常正常或偏低。目前的标准治疗包括终身补充钙和/或维生素 D。即使采用稳定的治疗方案，甲状旁腺功能减退患者仍可能出现对其生活质量产生负面影响的症状。

方法

2023 年 11 月 1 日进行了一项系统文献综述，以确定有关接受标准治疗的甲状旁腺功能减退症患者生活质量的当前知识。检索了 PubMed 和 Web of Science。系统评价已在 PROSPERO 中注册 (#CRD42023470924)。

结果

删除重复项后，留下 398 项研究进行标题和摘要筛选，之后纳入 30 项进行全文筛选。排除七项研究（其中五项研究缺乏对照人群、一项使用未经验证的问卷、一项是较大纳入研究的子样本）后，本系统评价纳入了 23 项研究。大多数纳入的研究都使用符合指南的甲状旁腺功能减退症定义，SF-36 是最常用的工具。几乎所有研究 (87%) 报告称，与正常人群或对照组相比，至少一个生活质量领域的得分在统计上显着较低。

结论

接受标准治疗的甲状旁腺功能减退症患者报告生活质量受损。造成这些损害的原因可能是多方面的，因此需要定期监测并让各种专业人员参与进来。