The domino annulation reactions of <i>o</i>‐aminotrifluoroacetophenone derivatives and MBH carbonates enabled by PPh₃ have been reported, which provide a series of tetrahydrofuro[3,2‐b]indolines containing a CF₃‐substituted tetrasubstituted carbon stereocenters in yields of 74 to 95% and >20:1 dr. In this process, MBH carbonates were used as C1/C3 synthons. The MTT assay shows that the products exhibit the activity of inhibitory effect on proliferation on Hela cancer cell line.

中文翻译：

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磷化氢催化邻氨基三氟苯乙酮衍生物与 Morita-Baylis-Hillman 碳酸盐的多米诺环化反应：四氢呋喃[3,2-b]二氢吲哚的构建

已经报道了由 PPh₃ 实现的 <i>o</i>-氨基三氟苯乙酮衍生物和 MBH 碳酸盐的多米诺环化反应，提供了一系列含有CF₃-取代的四取代碳立构中心，产率为 74% 至 95%，且 Dr. >20:1。在此过程中，MBH 碳酸盐用作 C1/C3 合成子。 MTT法检测显示产物对Hela癌细胞系具有增殖抑制活性。