Titanium (Ti) and its alloys have been widely employed in the treatment of orthopedics and other hard tissue diseases. However, Ti-based implants are bioinert and suffer from bacterial infections and poor osseointegration in clinical applications. Herein, we successfully modified Ti with a porous N-halaminated spermidine-containing polymeric coating (Ti-SPD-Cl) through alkali-heat treatment, surface grafting and chlorination, and it has both excellent antibacterial and osteogenic abilities to significantly enhance osseointegration. The as-obtained Ti-SPD-Cl contains abundant N–Cl groups and demonstrates effective antibacterial ability against S. aureus and E. coli. Meanwhile, due to the presence of the spermidine component and construction of a porous hydrophilic surface, Ti-SPD-Cl is also beneficial for maintaining cell membrane homeostasis and promoting cell adhesion, exhibiting good biocompatibility and osteogenic ability. The rat osteomyelitis model demonstrates that Ti-SPD-Cl can effectively suppress bacterial infection and enhance bone–implant integration. Thus, Ti-SPD-Cl shows promising clinical applicability in the prevention of orthopedic implant infections and poor osseointegration.

中文翻译：

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N-卤代亚精胺聚合物涂层使钛实现抗菌和骨整合双重功能

钛（Ti）及其合金已广泛应用于骨科和其他硬组织疾病的治疗。然而，钛基种植体具有生物惰性，在临床应用中容易出现细菌感染和骨整合不良等问题。在此，我们通过碱热处理、表面接枝和氯化成功用多孔N-卤代亚精胺聚合物涂层（Ti-SPD-Cl）对Ti进行改性，使其具有优异的抗菌和成骨能力，可显着增强骨整合。所得的 Ti-SPD-Cl 含有丰富的 N-Cl 基团，对金黄色葡萄球菌和大肠杆菌具有有效的抗菌能力。同时，由于亚精胺成分的存在和多孔亲水表面的构建，Ti-SPD-Cl也有利于维持细胞膜稳态和促进细胞粘附，表现出良好的生物相容性和成骨能力。大鼠骨髓炎模型表明Ti-SPD-Cl可以有效抑制细菌感染并增强骨-种植体整合。因此，Ti-SPD-Cl在预防骨科植入物感染和骨整合不良方面显示出有前景的临床应用前景。