One new highly degraded steroid, namely 21‐nor‐4‐ene‐chaxine A (1) furnishing a 5/6/5‐tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT‐ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti‐microglial inflammatory effect on lipopolysaccharide (LPS)‐induced inflammation in BV‐2 microglial cells.

中文翻译：

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来自南海海绵的抗炎类固醇Spongia officinalis

从南海海绵中分离出一种新的高度降解类固醇，即 21-nor-4-ene-chaxine A (1)，提供 5/6/5-三环，以及一种已知的相关类似物 (2) 。它们的结构（包括绝对构型）是通过广泛的光谱数据分析、TDDFT-ECD计算以及与文献中先前报道的光谱数据的比较来建立的。化合物 1 代表了 incisterols 家族的新成员，B 环高度降解。体外生物测定表明，化合物 2 对脂多糖 (LPS) 诱导的 BV-2 小胶质细胞炎症表现出显着的抗小胶质炎症作用。