The present manuscript contains critical and constructive views on the uses of comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) within the context of food analysis. Focus is devoted to the GC × GC-MS literature covering the period 2018–2023 (nearly 170 articles), even though the conclusions made can be applied, to some extent, to general ones. In fact, even though the use of GC × GC in food analysis has a publication history of just over two decades, it has never gained a firm hold in this field of application, in neither the industry nor in academia. Possible reasons for this lack, along with analytical challenges for which specific GC × GC-MS configurations would certainly be useful, are herein given.

中文翻译：

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2018-2023 年文献期间综合二维气相色谱-质谱法在食品分析中的应用的看法

本手稿包含关于在食品分析背景下使用综合二维气相色谱-质谱法 (GC × GC-MS) 的批判性和建设性观点。重点关注 2018-2023 年期间的 GC × GC-MS 文献（近 170 篇文章），尽管所得出的结论在某种程度上可以应用于一般结论。事实上，尽管气相色谱×气相色谱在食品分析中的应用只有二十多年的出版历史，但无论是在工业界还是在学术界，它都从未在这一应用领域站稳脚跟。本文给出了这种缺乏的可能原因，以及特定 GC × GC-MS 配置肯定有用的分析挑战。