In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.

中文翻译：

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平衡神经元活动以对抗神经发育障碍

在最近的一项研究中，Rylaarsdam 及其同事发现，引起罕见神经发育综合征的 PACS1 基因突变会影响人类神经元的放电能力，但不会导致大脑类器官的细胞结构失调。这些发现表明异常的神经元电生理学可能是损害大脑发育的儿科疾病的干预目标。