The nanomedicine system based on dual drug delivery systems (DDDs) can significantly enhance the efficacy of tumor treatment. Herein, a metal-organic framework, Zeolite imidazole salt frames 8 (ZIF-8), was successfully utilized as a carrier to load the dual chemotherapeutic drugs doxorubicin (DOX) and camptothecin (CPT), named DOX/CPT@ZIF-8 (denoted as DCZ), and their inhibitory effects on 4T1 breast cancer cells were evaluated. The study experimentally demonstrated the synergistic effects of the dual chemotherapeutic drugs within the ZIF-8 carrier and showed that the ZIF-8 nano-carrier loaded with the dual drugs exhibited stronger cytotoxicity and inhibitory effects on 4T1 breast cancer cells compared to single-drug treatment. The use of a ZIF-8-based dual chemotherapeutic drug carrier system highlighted its potential advantages in suppressing 4T1 breast cancer cells.

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基于金属有机框架平台的双重化疗药物递送系统在促进乳腺癌研究中肿瘤消退中的应用

基于双药物递送系统（DDDs）的纳米药物系统可以显着增强肿瘤治疗的功效。在此，金属有机骨架沸石咪唑盐框架8（ZIF-8）被成功地用作载体来负载双化疗药物阿霉素（DOX）和喜树碱（CPT），命名为DOX/CPT@ZIF-8（记为DCZ），并评估其对4T1乳腺癌细胞的抑制作用。该研究通过实验证明了ZIF-8载体内双化疗药物的协同作用，并表明负载双药物的ZIF-8纳米载体与单药治疗相比对4T1乳腺癌细胞表现出更强的细胞毒性和抑制作用。基于ZIF-8的双重化疗药物载体系统的使用凸显了其在抑制4T1乳腺癌细胞方面的潜在优势。