Abstract

Introduction

Historically, neuroblastoma has been diagnosed by surgical open biopsy (SB). In recent decades, core needle biopsy (CNB) has replaced surgical biopsy due to its safe and adequate method of obtaining tissue diagnosis.

Aim

Our study aimed to assess the effectiveness of CNB in obtaining tissue diagnosis for neuroblastoma and evaluate its safety profile in terms of post-operative complications, in comparison to SB.

Methods

A retrospective cohort study, including all patients younger than 18 years who were diagnosed with neuroblastoma from 2012 until 2022 in a single tertiary medical center. Patients’ demographics, tumor size and location, pathological results, and clinical outcomes were collected.

Results

79 patients were included in our study: 35 biopsies were obtained using image-guided CNB and 44 using SB. Patients’ and tumor characteristics including age, gender, tumor volume, and stage were similar in both groups. The biopsy adequacy rate in the CNB group was 91% and 3 patients in this group underwent repeated biopsy. The safety profile in the CNB group was similar to the SB group.

Conclusions

CNB is a safe method and should be considered the first choice for obtaining tissue diagnosis when feasible due to its high adequacy in terms of tumor histopathological features.

中文翻译：

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儿科人群神经母细胞瘤的经皮空心针活检：过去十年我们学到了什么

摘要

介绍

历史上，神经母细胞瘤是通过手术开放活检（SB）来诊断的。近几十年来，空心针活检（CNB）因其安全、充分的组织诊断方法而取代了手术活检。

目的

我们的研究旨在评估 CNB 在获得神经母细胞瘤组织诊断方面的有效性，并与 SB 相比评估其在术后并发症方面的安全性。

方法

一项回顾性队列研究，包括 2012 年至 2022 年在一个三级医疗中心诊断为神经母细胞瘤的所有 18 岁以下患者。收集患者的人口统计数据、肿瘤大小和位置、病理结果和临床结果。

结果

我们的研究纳入了 79 名患者：其中 35 名患者使用图像引导 CNB 获得活检，44 名患者使用 SB 获得。两组患者和肿瘤特征（包括年龄、性别、肿瘤体积和分期）相似。 CNB组的活检充分率为91%，该组中有3名患者接受了重复活检。 CNB 组的安全性与 SB 组相似。

结论

CNB 是一种安全的方法，由于其在肿瘤组织病理学特征方面的高度充分性，应被视为在可行的情况下获得组织诊断的首选。