Abstract

The Coronavirus disease-2019 (COVID-19) pandemic is a global concern, with updated pharmacological therapeutic strategies needed. Cancer patients have been found to be more susceptible to severe COVID-19 and death, and COVID-19 can also lead to cancer progression. Traditional medicinal plants have long been used as anti-infection and anti-inflammatory agents, and Moringa oleifera (M. oleifera) is one such plant containing natural products such as kaempferol, quercetin, and hesperetin, which can reduce inflammatory responses and complications associated with viral infections and multiple cancers. This review article explores the cellular and molecular mechanisms of action of M. oleifera as an anti-COVID-19 and anti-inflammatory agent, and its potential role in reducing the risk of cancer progression in cancer patients with COVID-19. The article discusses the ability of M. oleifera to modulate NF-κB, MAPK, mTOR, NLRP3 inflammasome, and other inflammatory pathways, as well as the polyphenols and flavonoids like quercetin and kaempferol, that contribute to its anti-inflammatory properties. Overall, this review highlights the potential therapeutic benefits of M. oleifera in addressing COVID-19 and associated cancer progression. However, further investigations are necessary to fully understand the cellular and molecular mechanisms of action of M. oleifera and its natural products as anti-inflammatory, anti-COVID-19, and anti-cancer strategies.

中文翻译：

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辣木及​​其生化化合物：针对 COVID-19 和相关癌症进展的潜在多靶点治疗剂

摘要

2019 年冠状病毒病 (COVID-19) 大流行是全球关注的问题，需要更新的药物治疗策略。研究发现癌症患者更容易感染严重的 COVID-19 并导致死亡，而 COVID-19 也可能导致癌症进展。传统药用植物长期以来被用作抗感染和抗炎剂，辣木（M. oleifera）就是这样一种植物，含有山奈酚、槲皮素和橙皮素等天然产物，可以减少炎症反应和与感染相关的并发症。病毒感染和多种癌症。这篇综述文章探讨了油橄榄作为抗 COVID-19 和抗炎剂的细胞和分子作用机制，及其在降低 COVID-19 癌症患者癌症进展风险方面的潜在作用。本文讨论了油茶调节 NF-κB、MAPK、mTOR、NLRP3 炎症小体和其他炎症途径的能力，以及有助于其抗炎特性的多酚和类黄酮（如槲皮素和山奈酚）。总体而言，本次综述强调了油橄榄在应对 COVID-19 和相关癌症进展方面的潜在治疗益处。然而，为了充分了解油橄榄及其天然产物作为抗炎、抗 COVID-19 和抗癌策略的细胞和分子作用机制，还需要进一步的研究。