The use of berberine hydrochloride (BCS class III) has limited application in psoriasis, when given as topical drug delivery systems, due to low permeability in the skin layer. Hence, berberine hydrochloride-loaded aquasome nanocarriers were developed for skin targeting, particularly epidermis (primary site of psoriasis pathophysiology) and enhance the skin permeability of berberine hydrochloride. Aquasomes were formulated using the adsorption method and characterized by structural morphology TEM, % drug adsorption, drug release profile (), efficacy study and stability study. The reduced particle size and higher surface charge of SKF3 formulation (263.57 ± 27.78 nm and −21.0 ± 0.43 mV) showed improved stability of aquasomes because of the development of higher surface resistance to formation of aggregates. The adsorption of hydrophilic berberine and the non-lipidic nature of aquasomes resulted in % adsorption efficiency (%AE) of 94.46 ± 0.39 %. The controlled first-order release behavior of aquasomes was reported to be 52.647 ± 14.63 and 32.08 ± 12.78 % in and studies, respectively. studies demonstrated that topical application of berberine hydrochloride loaded aquasomes significantly alleviated psoriasis symptoms like hyperkeratosis, scaling and inflammation, due to the reduction in the inflammatory cytokines (IL-17 and IL-23). Therefore, aquasome formulation exhibits an innovative approach for targeted application of berberine hydrochloride in the management of psoriasis.

中文翻译：

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基于纳米金刚石的小檗碱水体可增强表皮渗透性以治疗牛皮癣

当作为局部给药系统给药时，由于皮肤层的渗透性较低，盐酸小檗碱（BCS III 级）在银屑病中的应用受到限制。因此，开发了负载盐酸小檗碱的水体纳米载体用于皮肤靶向，特别是表皮（牛皮癣病理生理学的主要部位）并增强盐酸小檗碱的皮肤渗透性。使用吸附方法配制水体，并通过结构形态 TEM、药物吸附百分比、药物释放曲线 ()、功效研究和稳定性研究进行表征。 SKF3 配方的粒径减小和表面电荷更高（263.57 ± 27.78 nm 和 -21.0 ± 0.43 mV），显示出水体稳定性的改善，因为对聚集体形成的表面阻力更高。亲水性小檗碱的吸附和水体的非脂质性质导致吸附效率 (%AE) 为 94.46 ± 0.39 %。据报道，水体的受控一级释放行为分别为 52.647 ± 14.63 和 32.08 ± 12.78 % 和 研究。研究表明，由于炎症细胞因子（IL-17 和 IL-23）的减少，局部应用负载水体的盐酸小檗碱可显着缓解牛皮癣症状，如角化过度、鳞屑和炎症。因此，水体制剂展示了盐酸小檗碱靶向应用治疗牛皮癣的创新方法。