Objectives SARS-CoV2 infection is reported to induce transaminase elevations. There are case reports of severe liver injury in adult SARS-CoV2 patients and some have theorized that acute SARS-CoV2 infection may be a driver of severe liver injury in children. While pediatric hepatic injury has previously been described, clear shifts in immunogenic response secondary to prior immune exposure and vaccination since initial reports from 2020 warrant further evaluation. We sought to identify the impact of variant shifts and vaccination on this phenomenon in children.

中文翻译：

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年龄较大和疫苗接种可防止儿童 SARS-CoV2 转氨酶升高

目标 据报道，SARS-CoV2 感染会导致转氨酶升高。有成人 SARS-CoV2 患者严重肝损伤的病例报告，一些人推测急性 SARS-CoV2 感染可能是儿童严重肝损伤的驱动因素。虽然之前已经描述过小儿肝损伤，但自 2020 年初次报告以来，继发于先前免疫暴露和疫苗接种的免疫原性反应发生明显变化，值得进一步评估。我们试图确定变异转变和疫苗接种对儿童这一现象的影响。