Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always overexpressed in the tumor, and controlling cell growth and metabolic activities, has an important role in both autophagy and ferroptosis. Interestingly, the selective types of autophay plays an important role in promoting ferroptosis, which is related to mTOR and some metabolic pathways (especially in iron and amino acids). In this paper, we list the main mechanisms linking ferroptosis with mTOR signaling pathway and further summarize the current compounds targeting ferroptosis in these ways. There are growing experimental evidences that targeting mTOR and ferroptosis may have effective impact in many tumors, and understanding the mechanisms linking mTOR to ferroptosis could provide a potential therapeutic approach for tumor treatment.

铁死亡是一种新型的程序性死亡，依赖于铁离子和氧化应激，主要是细胞内的脂质过氧化形式。近年来，铁死亡对于靶向肿瘤的治疗机制越来越引起人们的兴趣。 mTOR 在肿瘤中总是过度表达，并控制细胞生长和代谢活动，在自噬和铁死亡中发挥重要作用。有趣的是，选择性类型的自噬在促进铁死亡中发挥着重要作用，这与mTOR和一些代谢途径（尤其是铁和氨基酸）有关。在本文中，我们列出了铁死亡与mTOR信号通路联系的主要机制，并进一步总结了目前针对铁死亡的化合物。越来越多的实验证据表明，靶向 mTOR 和铁死亡可能对许多肿瘤产生有效影响，并且了解 mTOR 与铁死亡之间的联系机制可以为肿瘤治疗提供潜在的治疗方法。