Introduction. Metaplastic breast carcinoma (MBC) is a rare subgroup of breast neoplasms associated with adverse outcomes because of its aggressive nature. Typically, MBCs show triple-negative hormone receptor (HR) status. Determining the HR status of breast cancer is an integral part because it is an important prognostic factor and helps in the treatment course of the disease. This study aimed to determine the HR status of MBC, its significance, and its association with various clinicopathological parameters. Methods. This was a retrospective study conducted at the Department of Histopathology, Liaquat National Hospital. A total of 140 biopsy-proven cases of MBC were enrolled in the study. Clinical and pathological data were retrieved from the institutes’ archives. Immunohistochemical studies were conducted to determine the estrogen receptor (ER) and progesterone receptor (PR) status. Results. The mean age of MBC in our population was found to be 52.18 ± 12.19 years. The HR positivity rate in our population was found to be 32.9%. A significant association was found between HR status and tumor laterality, tumor size, tumor grade, tumor stage, and recurrence. ER/PR-negative MBCs were most probably associated with higher grade and higher tumor stage and were larger in size (6.62 ± 3.43 cm) than ER/PR-positive MBCs (4.20 ± 1.88 cm). Moreover, ER/PR-positive MBCs showed a higher recurrence rate than ER/PR-negative MBCs (43.5% vs. 25.5%, respectively). No statistically significant relationship was found between HR status and patient age, histological subtype, or survival rate. Conclusion. MBC is a rare breast neoplasm. MBC was found to be triple negative in most cases, but a significant percentage were HR (ER/PR) positive. Moreover, we found an association between HR status and various clinicopathological features, indicating that HR status is a significant predictor of MBC prognosis.

中文翻译：

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雌激素/孕激素受体表达在化生性乳腺癌中的意义

介绍。化生性乳腺癌（MBC）是一种罕见的乳腺肿瘤亚组，因其侵袭性而导致不良后果。通常，MBC 显示三阴性激素受体 (HR) 状态。确定乳腺癌的 HR 状态是不可或缺的一部分，因为它是重要的预后因素，有助于疾病的治疗过程。本研究旨在确定 MBC 的 HR 状态、其意义及其与各种临床病理参数的关联。方法。这是一项在利亚卡特国立医院组织病理学部进行的回顾性研究。共有 140 例经活检证实的 MBC 病例参加了该研究。从研究所的档案中检索临床和病理数据。进行免疫组织化学研究以确定雌激素受体（ER）和孕激素受体（PR）状态。结果。我们的人群中 MBC 的平均年龄为 52.18 ± 12.19 岁。我们人群的 HR 阳性率为 32.9%。研究发现 HR 状态与肿瘤偏侧性、肿瘤大小、肿瘤分级、肿瘤分期和复发之间存在显着关联。 ER/PR 阴性 MBC 最有可能与较高级别和较高肿瘤分期相关，并且尺寸 (6.62 ± 3.43 cm) 大于 ER/PR 阳性 MBC (4.20 ± 1.88 cm)。此外，ER/PR 阳性 MBC 的复发率高于 ER/PR 阴性 MBC（分别为 43.5% 和 25.5%）。 HR 状态与患者年龄、组织学亚型或生存率之间没有发现统计学上显着的关系。结论。 MBC 是一种罕见的乳腺肿瘤。在大多数情况下，MBC 呈三阴性，但很大一部分为 HR (ER/PR) 阳性。此外，我们发现 HR 状态与各种临床病理特征之间存在关联，表明 HR 状态是 MBC 预后的重要预测因子。