Atherogenic index of plasma (AIP) represents a novel marker in the current era of cardiovascular diseases. In this meta-analysis, we aimed to evaluate the association of AIP with cardiovascular prognosis in patients with coronary artery disease (CAD). PubMed, Scopus, and Web of Science databases were searched from inception through 2024. The primary outcome was major cardiovascular events (MACE). The secondary outcomes included all-causes death, cardiovascular death, myocardial infarction (MI), stroke, revascularization, and no-reflow phenomenon. AIP was determined by taking the logarithm of the ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C). The data analysis was represented using the risk ratio (RR) along with a 95% confidence interval (CI). Sixteen studies with a total number of 20,833 patients met the eligible criteria. The pooled-analysis showed a significant increased risk of MACE in the highest AIP group compared with the lowest AIP group (RR = 1.63; 95% CI, 1.44–1.85; P < 0.001). A similar result was observed when AIP was regarded as a continuous variable (RR = 1.54; 95% CI, 1.30–1.83; P < 0.001). Besides, elevated AIP was associated with increased risk of cardiovascular death (RR = 1.79; 95% CI, 1.09–2.78; P = 0.02), MI (RR = 2.21; 95% CI, 1.55–3.13; P < 0.001), revascularization (RR = 1.62; 95% CI, 1.34–1.97; P < 0.001), no-reflow phenomenon (RR = 3.12 95% CI, 1.09–8.96; P = 0.034), and stent thrombosis (RR = 13.46; 95%CI, 1.39-129.02; P = 0.025). However, AIP was not significantly associated with the risk of all-causes death and stroke among patients with CAD. The results of this study demonstrated that increased AIP is an independent prognostic factors in patients with CAD. Further research is warranted to elucidate the potential development of targeted interventions to modify AIP levels and improve patient outcomes.

中文翻译：

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冠状动脉疾病患者血浆致动脉粥样硬化指数与心血管结局的关联：系统评价和荟萃分析

血浆致动脉粥样硬化指数（AIP）代表了当今心血管疾病的新标志物。在这项荟萃分析中，我们旨在评估 AIP 与冠状动脉疾病 (CAD) 患者心血管预后的关系。对 PubMed、Scopus 和 Web of Science 数据库的检索从最初到 2024 年。主要结果是主要心血管事件 (MACE)。次要结局包括全因死亡、心血管死亡、心肌梗死（MI）、中风、血运重建和无复流现象。 AIP通过甘油三酯(TG)与高密度脂蛋白胆固醇(HDL-C)之比的对数来确定。数据分析使用风险比 (RR) 和 95% 置信区间 (CI) 来表示。共有 20,833 名患者参与的 16 项研究符合合格标准。汇总分析显示，与 AIP 最低组相比，AIP 最高组的 MACE 风险显着增加（RR = 1.63；95% CI，1.44–1.85；P < 0.001）。当 AIP 被视为连续变量时，观察到类似的结果（RR = 1.54；95% CI，1.30-1.83；P < 0.001）。此外，AIP升高与心血管死亡风险增加相关（RR = 1.79；95% CI，1.09-2.78；P = 0.02）、MI（RR = 2.21；95% CI，1.55-3.13；P < 0.001）、血运重建风险增加（RR = 1.62；95% CI，1.34–1.97；P < 0.001）、无复流现象（RR = 3.12 95% CI，1.09–8.96；P = 0.034）和支架血栓（RR = 13.46；95% CI） ，1.39-129.02；P = 0.025）。然而，AIP 与 CAD 患者的全因死亡和中风风险并无显着相关性。本研究结果表明，AIP 升高是 CAD 患者的独立预后因素。需要进一步的研究来阐明有针对性的干预措施的潜在发展，以改变 AIP 水平并改善患者的治疗结果。