Acute Bacterial Skin and Skin Structure Infections (ABSSSI) are marked by substantial morbidity, frequent need for hospitalization, and long courses of intravenous antibiotic therapy. Herein, we report four cases of pediatric patients admitted for ABSSSI and managed with a combination antibiotic regimen incorporating dalbavancin: a second-generation lipoglycopeptide active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In our experience, particularly in a setting with a high methicillin-resistance rate, dalbavancin demonstrated safety and efficacy, simplifying ABSSSI management in childhood. Its prolonged half-life enables a single-dose administration regimen, offering potential solutions to numerous challenges encountered in pediatric care, such as extended hospital stays, difficulties in securing and maintaining vascular access, lack of pediatric-specific drug indications, and limited availability of suitable oral formulations.

中文翻译：

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达巴万星治疗儿科急性细菌性皮肤和皮肤结构感染：持续治疗经验的见解

急性细菌性皮肤和皮肤结构感染 (ABSSSI) 的特点是发病率高、经常需要住院治疗以及长期静脉注射抗生素治疗。在此，我们报告了四例因 ABSSSI 入院的儿科患者，并采用包含达巴万星的联合抗生素治疗方案进行治疗：达巴万星是一种第二代脂糖肽，可有效对抗革兰氏阳性菌，包括耐甲氧西林金黄色葡萄球菌。根据我们的经验，特别是在甲氧西林耐药率较高的环境中，达巴万星表现出安全性和有效性，简化了儿童时期的 ABSSSI 管理。其较长的半衰期使得单剂量给药方案成为可能，为儿科护理中遇到的众多挑战提供了潜在的解决方案，例如住院时间延长、确保和维持血管通路的困难、缺乏儿科特定药物适应症以及药物供应有限等。合适的口服制剂。