Since the discovery of membrane contact sites between ER and mitochondria called mitochondria-associated membranes (MAMs), several pieces of evidence identified their role in the regulation of different cellular processes such as Ca signalling, mitochondrial transport, and dynamics, ER stress, inflammation, glucose homeostasis, and autophagy. The integrity of these membranes was found to be essential for the maintenance of these cellular functions. Accumulating pieces of evidence suggest that MAMs serve as a platform for autophagosome formation. However, the alteration within MAMs structure is associated with the progression of neurodegenerative diseases. Dysregulated autophagy is a hallmark of neurodegeneration. Here, in this review, we highlight the present knowledge on MAMs, their structural composition, and their roles in different cellular functions. We also discuss the association of MAMs proteins with impaired autophagy and their involvement in the progression of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

中文翻译：

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线粒体相关膜蛋白和自噬的相互作用：对神经退行性变的影响

自从发现 ER 和线粒体之间的膜接触位点（称为线粒体相关膜 (MAM)）以来，一些证据确定了它们在调节不同细胞过程中的作用，例如 Ca 信号传导、线粒体转运和动力学、ER 应激、炎症、葡萄糖稳态和自噬。人们发现这些膜的完整性对于维持这些细胞功能至关重要。越来越多的证据表明，MAM 可作为自噬体形成的平台。然而，MAM 结构的改变与神经退行性疾病的进展有关。自噬失调是神经退行性疾病的标志。在这篇综述中，我们重点介绍了目前关于 MAM 的知识、它们的结构组成以及它们在不同细胞功能中的作用。我们还讨论了 MAM 蛋白与自噬受损的关系及其与阿尔茨海默病和帕金森病等神经退行性疾病进展的关系。